C. Gälman
Karolinska University Hospital
9 Papers
1 Citations
C. Gälman is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Internal medicine & Cholesterol. The author has an hindex of 7, co-authored 9 publications.
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Papers
The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
C. Gälman,Tomas Lundåsen,Alexei Kharitonenkov,Holly A. Bina,Mats Eriksson,Ingiäld Hafström,Maria Dahlin,Per Åmark,Bo Angelin,Mats Rudling +9 more
TL;DR: Serum FGF21 varied 250-fold among 76 healthy individuals and did not relate to age, gender, body mass index (BMI), serum lipids, or plasma glucose, and the wide interindividual variation and the induction of ketogenesis independent of F GF21 levels indicate that the physiological role of FGF 21 in humans may differ from that in mice.
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Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.
TL;DR: Evidence is provided that the transintestinal flux of BAs regulates serum levels of intestinal fibroblast growth factor 19 (FGF19) that in turn modulate BA production in human liver, and that FGF19 modulates hepatic BA synthesis.
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Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.
TL;DR: Bile acid synthesis in humans has a diurnal rhythm, with 2 peaks during the daytime, that is opposite from the circadian rhythm of cholesterol synthesis, which indicates the presence of an important species variation in the regulation of cholesterol homeostasis.
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Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19
TL;DR: Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19 (Rapid Communication).
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Importance of Proprotein Convertase Subtilisin/Kexin Type 9 in the Hormonal and Dietary Regulation of Rat Liver Low-Density Lipoprotein Receptors
TL;DR: The identification of PCSK9 regulation by these various treatments is important in understanding of the physiological function of this protein and points to new targets for therapeutic treatments to increase hepatic LDLR numbers.
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