B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL.

Prognostic Importance of Serum Soluble CD23 Level in Chronic Lymphocytic Leukemia

Synthese des donnees recentes sur le recepteur des IgE a faible affinite (FceRII). Les deux autres types de proteines de liaison des IgE ― le recepteur a affinite elevee et les facteurs de liaison des IgE produits par les lymphocytes sont abordes uniquement pour leurs relations potentielles avec le FceRII ou la forme soluble du FceRII. Les fonctions du FceRII sont d'une part un recepteur d'immunoglobuline et d'autre part un facteur de croissance et de differenciation des lymphocytes B

Fc epsilon RII/CD23: the low affinity receptor for IgE.

The low-affinity receptor for IgE (FceRII or CD23) is the only FcR which does not belong to the same gene superfamily as its ligand; i.e., the immunoglobulin superfamily (Fridman 1991). Historically, this molecule has been discovered independently either as an IgE receptor on human lymphoblastoid B cells (GonzalezMolina et al. 1976), as a cell surface marker specifically expressed on EpsteinBarr virus-transformed B cells (EBVCS) (Kintner et al. 1981) or as a B-cell activation antigen (Blast 2) (Thorley-Lawson et al. 1985). These considerations, together with the subsequent finding that FcsRII displays a significant homology with a large family of calcium-dependent (C-type) animal lectins, already suggest the existence of natural ligands other than IgE. However, in spite of more recent and very strong evidence supporting this view, this ligand(s) remains to be identified. Similar to most FcR, a soluble form of FceRII is released in the extracellular fluid. These soluble fragments formed by the proteolytic cleavage of surface FceRII are not only capable of binding IgE (IgE-binding factors) but also, and perhaps more importantly, they appear to exert multiple functions that are IgE-independent. Hence, FcfRII may be viewed not only as a low-affinity IgE receptor expressed on the surface of several cell types, but also as the membrane precursor of a soluble lymphokine with pleiotropic activities. It must be underlined that, to date, this view is still speculative inasmuch as the only function of CD23 which has been unequivocally documented in vivo is its ability to bind IgE, whereas all the other activities ascribed to CD23 or its soluble form have been observed in vitro. After a brief summary of current knowledge regarding the structure, the cellular distribution and the regulation of FccRII expression, reviewed in detail very recently (Conrad 1990, Delespesse et al. 1991, Richards et al. 1991), we will discuss the multiple activities ascribed to this intriguing molecule.

The low-affinity receptor for IgE.

Adenosine Triphosphate–Induced Shedding of CD23 and L-Selectin (CD62L) From Lymphocytes Is Mediated by the Same Receptor but Different Metalloproteases

Serum soluble CD23 is a prognostic marker in chronic lymphocytic leukemia (CLL) and stage IV lymphocytic lymphoma (LL)

Elevation of IgE-binding factors in serum of patients with B cell-derived chronic lymphocytic leukemia.

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Serum soluble CD23 is a prognostic marker in chronic lymphocytic leukemia (CLL) and stage IV lymphocytic lymphoma (LL)

Elevation of IgE-binding factors in serum of patients with B cell-derived chronic lymphocytic leukemia.