C. E. Herron
University of Bristol
5 Papers
339 Citations
C. E. Herron is an academic researcher from University of Bristol. The author has contributed to research in topics: NMDA receptor & Excitatory postsynaptic potential. The author has an hindex of 4, co-authored 5 publications.
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Papers
Synaptic activation of N-methyl-D-aspartate receptors in the Schaffer collateral-commissural pathway of rat hippocampus.
TL;DR: It is suggested that NMDA receptors can contribute a low‐threshold and long‐duration monosynaptic component of the response evoked by low‐frequency stimulation of the Schaffer collateral‐commissural pathway which is prevented by concurrently activated IPSPs which rapidly hyperpolarize neurones into a region where Mg2+ substantially blocks NMDA channels.
293
Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus.
TL;DR: It is suggested that during high‐frequency stimulation a neurone may become depolarized for a sufficient time to reduce the Mg2+ block of NMDA channels in order to contribute transiently to the synaptic response, despite the inhibitory synaptic mechanisms which prevent its activation during single‐shock stimulation.
233
A selective N-methyl-d-aspartate antagonist depresses epileptiform activity in rat hippocampal slices
TL;DR: Intracellular recordings in the presence of bicuculline showed that D-APV reduced the late component of the excitatory postsynaptic potential and the number of action potentials evoked synaptically.
211
Intracellular demonstration of an N-methyl-d-aspartate receptor mediated component of synaptic transmission in the rat hippocampus
TL;DR: It is proposed that Mg2+ normally prevents expression of NMDA receptor-mediated responses during low-frequency stimulation, but during a period of tetanic stimulation cells may depolarize sufficiently to allow a significant NMDA component of the response to be manifest and initiate long-term potentiation.
137
Plasticity-Related Synaptic Mechanisms in Hippocampus
Graham L. Collingridge,C. E. Herron,Robin A. J. Lester +2 more
- 01 Jan 1988
TL;DR: The characteristics of NMDA and non-NMDA components of synaptic transmission in the hippocampus have been compared during low frequency transmission in depolarised cells and high frequency transmission under normal conditions and show a slower rising and longer lasting synaptic response.
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