C. de Wit
University of Lübeck
13 Papers
202 Citations
C. de Wit is an academic researcher from University of Lübeck. The author has contributed to research in topics: Vasodilation & Endothelium. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of C. de Wit include Ludwig Maximilian University of Munich.
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Papers
Endothelial-specific deletion of Connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
Christos Chadjichristos,K.E.L. Scheckenbach,T. A. B. van Veen,M. Z. Richani Sarieddine,C. de Wit,Zhihong Yang,Isabelle Roth,Marc Bacchetta,Hema Viswambharan,Bernard Foglia,Tecla Dudez,M.J.A. van Kempen,F.E.J. Coenjaerts,Lucile Miquerol,Urban Deutsch,Habo J. Jongsma,Marc Chanson,Brenda R. Kwak +17 more
TL;DR: Cx40-mediated gap junctional communication contributes to a quiescent nonactivated endothelium by propagating adenosine-evoked antiinflammatory signals between endothelial cells, thus accelerating atherosclerosis.
137
Large arterioles in the control of blood flow: role of endothelium‐dependent dilation
TL;DR: Recent intravital microscopic studies suggest that large resistance vessels are under tight control of endothelial factors such as nitric oxide and endothelium-derived hyperpolarising factor (EDHF).
108
Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular disease.
Guillermo Pérez de Lema,Francisco Javier Lucio-Cazaña,Alvaro Molina,Bruno Luckow,Holger Schmid,C. de Wit,Victoria Moreno-Manzano,Bernhard Banas,Francisco Mampaso,Detlef Schlöndorff +9 more
TL;DR: TRA treatment reduces lymphoproliferation and glomerulonephritis in MRL/lpr mice, which occurs in spite of unaltered anti-DNA titers and glomersular immune complex deposition, and cannot be overcome by T-cell transfer from nephritic mice.
97
Synergistic action of vasodilators that increase cGMP and cAMP in the hamster cremaster microcirculation
C. de Wit,P. Von Bismarck,U Pohl +2 more
TL;DR: Continuous release of NO and prostaglandins by the endothelium may not only modulate the efficacy of such cyclic nucleotide increasing vasodilators but also interact synergistically in controlling basal vascular tone.
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Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
TL;DR: Since Cx40 can be replaced by Cx45, a connexin with a significantly lower conductivity, it is suggested that the regulation of renin release is not dependent on the unique electrical properties of these channel proteins.
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