Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis.

Acute pharmacotherapy of depression in old age: A systematic analysis focussing on numbers needed to treat

Zu den Antidepressiva, die selektiv sowohl auf das serotonerge als auch auf das noradrenerge System wirken, zahlen: 


Milnacipran


Mirtazapin


Venlafaxin

Serotonin-Noradrenalin-selektive Antidepressiva (SNRI/NaSSA)

Serotonin reuptake and receptor blockers

<title>Abstract</title> Background The COVID-19 pandemic significantly disrupted healthcare systems, particularly affecting vulnerable populations such as children and individuals with special needs, causing delays and reductions in routine dental services. The aim of this study was to evaluate the accessibility of dental services and identify determinants of access to oral health care for children aged 0–13 years during the COVID-19 pandemic restriction period. Methods We used a mixed-method research design. This cross-sectional study included 270 children aged 0 to 13 years who visited Ege University Pediatric Dental Clinics between August 2021 and February 2022. Interviewer-administered questionnaires collected information about sociodemographic and economic characteristics, as well as dental service utilization during the pandemic. "Access" to receive oral health care to address existing dental problems is defined separately for each application to the institution. Qualitative data from 16 in-depth interviews were analysed using thematic analysis to explore the barriers to accessing oral healthcare during the COVID-19 pandemic. Results During the pandemic, 62.3% of dental institutions' applications failed to access care. Parental education, employment status, and household income significantly affected access (<italic>p</italic> &lt; 0.005). Multiple logistic regression revealed that applying to university clinics (OR = 4.78; 95% CI 2.24–10.21) and private institutions (OR = 4.33; 95% CI 2.30–8.17) led to higher access rates when compared to public dental centres. The father's regular employment (OR = 3.39; 95% CI 1.37–8.34) and the child's previous dental contacts (OR = 2.37; 95% CI 1.21–4.62) increased the likelihood of accessing oral healthcare. The risk of contracting infections and income loss were pandemic related barriers. The most common barriers were those concerning the availability of services at public dental clinics. Children with disabilities faced further barriers due to the risk of infection, difficulty reaching institutions, and unmet dental needs for treatment under general anaesthesia. Conclusion Higher socioeconomic status and past contact with dentists had a positive effect on oral healthcare access. Dental services provided by public institutions had a lower level of access. The COVID-19 pandemic highlighted oral healthcare inequalities, particularly for those children with disabilities in Türkiye. Policymakers should strengthen public health crisis plans in order to improve children's oral healthcare access. 

Access to oral healthcare for children during the COVID-19 pandemic: A mixed-methods study in the Aegean Region of Türkiye

Special needs children presenting with dental problems were penalised during the Covid-19 pandemic due to the reduction of clinical activity and the risks of nosocomial infection. The aim of this study is to evaluate the impact of the pandemic on oral healthcare in paediatric special needs patients.We retrospectively assessed and compared the outpatient clinic activity and dental procedures performed under general anaesthesia in children with special needs at Brescia Children's Hospital (Italy) in 2019, 2020, and 2021. Any delay between expected waiting time based on assigned priority and surgery was recorded. The efficacy of the protocol adopted to reduce the spread of Covid-19 was evaluated by reporting any infections in patients, parents, and health care providers.In 2020, 270 outpatient visits were performed, and 40 patients were treated under general anaesthesia, with a 26% and 65% reduction, respectively, compared to 2019. In 2021, 362 visits were performed (similar to 2019) and 48 patients were treated under general anaesthesia (58% compared to 2019). The mean delay in the planned treatment was 1.0 month in 2019 (pre-pandemic period), 2.1 months in 2020, and 1.1 month in 2021. No cases of Covid-19 infection were reported in the cohort of patients and parents or among the operators related to nosocomial infection.The Covid-19 pandemic has profoundly reduced the activity of general anaesthesia in paediatric special need patients during 2020, with a gradual return to normal pre-pandemic activity in 2021. The adopted protocol prevented the spread of COVID-19 during hospitalisation. 

https://link.springer.com/content/pdf/10.1007/s40368-022-00770-2.pdf

Impact of Covid-19 pandemic on children with special needs requiring general anaesthesia for the treatment of dental disease: the experience of the Brescia Children’s Hospital, Lombardy, Italy

P.1.112 Double-blind, randomized study of venlafaxine, clomipramine, and trazodone in geriatric patients with major depression

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Impact of Covid-19 pandemic on children with special needs requiring general anaesthesia for the treatment of dental disease: the experience of the Brescia Children’s Hospital, Lombardy, Italy

P.1.112 Double-blind, randomized study of venlafaxine, clomipramine, and trazodone in geriatric patients with major depression