C. Compton
Novartis
5 Papers
38 Citations
C. Compton is an academic researcher from Novartis. The author has contributed to research in topics: Asthma & Sputum. The author has an hindex of 2, co-authored 5 publications.
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Papers
The Innovative Medicines Initiative (IMI): a new opportunity for scientific collaboration between academia and industry at the European level.
TL;DR: The largest European public–private partnership in biomedical research, the Innovative Medicines Initiative (IMI), is launched, a unique pan-European research and development initiative with the strategic focus of strengthening the competitiveness of European Union (EU)-based biopharmaceutical industry.
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•Journal Article
Unbiased clustering of children with asthma or pre-school wheeze using the U-BIOPRED electronic nose platform
Paul Brinkman,Simone Hashimoto,Louise Fleming,G. Hedlin,Hugo H. Knobel,Teunis J. Vink,Nicholas J. W. Rattray,Marco Santonico,Giorgio Pennazza,Anthony V. D'Amico,Paolo Montuschi,Steve J. Fowler,Julie Corfield,Anthony Rowe,P.F Singer,P.F Singer,Urs Frey,Hans Bisgaard,Andrew Bush,Scott Wagers,K.F. Chung,Dominic E. Shaw,Ioannis Pandis,C. Compton,W. Siebold,Aruna T. Bansal,Graham Roberts,W.M.C. van Aalderen,P. J. Sterk +28 more
TL;DR: In this preliminary analysis, unbiased fingerprinting by eNose provides clinical clusters of children with asthma or pre-school wheeze, which suggests that metabolomics in exhaled air is suitable for phenotyping of airways disease in childhood.
4
•Journal Article
Clustering analysis of clinical variables in U-BIOPRED adult asthma cohort
Diane Lefaudeux,Bertrand De Meulder,Kian Fan Chung,Graham Roberts,Matthew J. Loza,Frédéric Baribaud,Ana R. Sousa,Aruna T. Bansal,Anthony Rowe,Ioannis Pandis,Alun Bedding,Amphun Chaiboonchoe,Hassan Ahmed,Charles Auffray,C. Compton,David Myles,Ratko Djukanovic,Dominic E. Shaw,Ildiko Horvath,Jacek Musiał,Julie Corfield,Pascal Chanez,Norbert Krug,Paolo Montuschi,Per Bakke,Peter J. Sterk,Riccardo Polosa,Scott Wagers,Florian Singer,Stephen J. Fowler,Sven-Erik Dahlén,Thomas Sandström,Timothy Higenbottam,Ulf Nihlén,Urs Frey,Wolfgang Seibold +35 more
TL;DR: This preliminary analysis shows that clinical variables from the U-BIOPRED cohort can be used to derive phenotypic asthma clusters that are similar but not identical to previously published ones.
3
•Journal Article
Associated factors with persistent airflow limitation in asthma in U-BIOPRED
Ariane H. Wagener,David Gibeon,Xian Yang,Ana R. Sousa,Julie Corfield,Dominic E. Shaw,Stephen J. Fowler,Louise Fleming,John H. Riley,L. Jeyasingham,Anthony Rowe,K. Fichtner,Graham Roberts,Per Bakke,Florian Singer,Thomas Geiser,Urs Frey,I. Horvarth,Riccardo Polosa,Klaus Bønnelykke,Norbert Krug,Roelinde Middelveld,SE Dahlen,B. Dahlén,G. Hedlin,Simone Hashimoto,Björn Nordlund,Jacek Musiał,A. Woodcock,C.S. Murray,Laurie Pahus,Pascal Chanez,David Myles,C. Compton,Timothy Higenbottam,Paolo Montuschi,Jørgen Vestbo,L. Larsson,Thomas Sandström,Hans Bisgaard,Scott Wagers,Peter H. Howarth,E.H.D. Bel,Ratko Djukanovic,Fan Chung,P. J. Sterk +45 more
TL;DR: A preliminary analysis of the U-BIOPRED cohort shows that fixed airflow limitation in asthma is associated with elevated sputum eosinophils and lower sputu alveolar macrophages, suggesting a distinguishable inflammatory profile in the airways.
1
•Journal Article
Clinical and histological comparison of smoking and non-smoking patients with severe asthma in the U-BIOPRED cohort
P.P. Hekking,Susan J. Wilson,Ariane H. Wagener,Ana R. Sousa,Julie Corfield,Dominic E. Shaw,Stephen J. Fowler,Louise Fleming,John H. Riley,E. Jeyasingham,Anthony Rowe,Wolfgang Seibold,Graham Roberts,Per Bakke,Florian Singer,Thomas Geiser,Urs Frey,Ildiko Horvath,Riccardo Polosa,Norbert Krug,Jacek Musiał,Laurie Pahus,David Myles,C. Compton,Timothy Higenbottam,Paolo Montuschi,Ulf Nihlén,Thomas Sandström,Scott Wagers,Peter H. Howarth,Ratko Djukanovic,K.F. Chung,Ioannis Pandis,Yike Guo,Aruna T. Bansal,E.H.D. Bel,P. J. Sterk +36 more
TL;DR: In this paper, a cross-sectional analysis of the U-BIOPRED adult severe asthma cohort was carried out to compare clinical, inflammatory and histological characteristics between smoking and non-smoking severe asthma patients.
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