Purpose
Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors comprising various breast cancers simply defined by the absence of estrogen receptor, progesterone receptor and overexpression of human epidermal growth factor receptor 2 gene In this review, we discuss the epidemiology, risk factors, clinical characteristics and prognostic variables of TNBC, and present the summary of recommended treatment strategies and all other available treatment options

An Overview of Triple-Negative Breast Cancer

Meta-analysis of the association of breast cancer subtype and pathologic complete response to neoadjuvant chemotherapy☆

The major current conventional types of metastatic breast cancer (MBC) treatments include surgery, radiation, hormonal therapy, chemotherapy, or immunotherapy. Introducing biological drugs, targeted treatment and gene therapy can potentially reduce the mortality and improve the quality of life in patients with MBC. However, combination of several types of treatment is usually recommended. Triple negative breast cancer (TNBC) accounts for 10–20% of all cases of breast carcinoma and is characterized by the low expression of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2). Consequently, convenient treatments used for MBC that target these receptors are not effective for TNBC which therefore requires special treatment approaches. This review discusses the occurrence of MBC, the prognosis and predictive biomarkers of MBC, and focuses on the novel advanced tactics for treatment of MBC and TNBC. Nanotechnology-based combinatorial approach for the suppression of EGFR by siRNA and gifitinib is described.

/pdf/metastatic-and-triple-negative-breast-cancer-challenges-and-1tdrraq0p1.pdf

Metastatic and triple-negative breast cancer: challenges and treatment options.

Annual San Antonio Breast Cancer Symposium に参加して

Targeting triple-negative breast cancer: optimising therapeutic outcomes

A Retrospective Analysis of Platinum-Based Neoadjuvant Chemotherapy for Local Advanced Triple Negative Breast Cancer

Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer

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A Retrospective Analysis of Platinum-Based Neoadjuvant Chemotherapy for Local Advanced Triple Negative Breast Cancer

Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer