Opioid analgesics are used commonly in end-stage cancer patients for pain treatment. Central nervous system adverse effects are rare. A73-year-old female patient was admitted to the emergency department for auditory and visual hallucinations. The patient had been receiving palliative treatment for liver, cervical, and lumbar bone metastases from an unknown origin. The patient used a transdermal fentanyl patch for palliative pain management and metoclopramide hydrochloride for nausea and vomiting. The patient had suffered weight loss of 10 kg within 5 months, and laboratory findings revealed hypoalbuminemia. The patient was considered to have experienced a fentanyl overdose, and the transdermal fentanyl patch treatment was stopped. The hallucinations improved during follow-up, and the patient was discharged with a dose adjustment. End-stage cancer patients with weight loss and hypoalbuminemia may be more prone to opioid adverse effects, such as hallucinations. The dose of fentanyl must be adjusted for weight loss, and correction of hypoalbuminemia may also lower the incidence of such adverse effects.

Neuropsychiatric side effects due to a transdermal fentanyl patch: hallucinations

Abstract Background Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally‐occurring AP. Hypothesis or Objectives Evaluate measures of oxidant status in dogs with AP and explore whether these measures correlate with AP severity. Animals Fifteen dogs with AP and 9 control dogs. Methods Prospective, controlled observational study. Plasma reactive metabolite (RM) concentrations, antioxidant potential (AOP), and urinary F2 isoprostane concentrations were measured in AP dogs and healthy controls. Severity of AP was assessed by length of hospitalization and 3 disease severity indices: canine acute pancreatitis severity (CAPS), modified canine activity index (M‐CAI), and the acute patient physiologic and laboratory evaluation score (APPLEfull). Results Reactive metabolite (RM) concentrations (median, 65 relative fluorescent units [RFU]/μL; range, 20‐331 RFU/μL) and RM:AOP (median, 7; range, 4‐109) were higher in AP dogs than healthy controls (median RM, 25 RFU/μL; range, 16‐41 RFU/μL; median RM:AOP, 4; range, 2‐7; P < .001 for both comparisons). Reactive metabolite (r S = 0.603, P = .08) and RM:AOP (r S = 0.491, P = .06) were not correlated with the duration of hospitalization or disease severity indices evaluated. However, disease severity indices did not predict mortality in our study. Normalized urine 2,3‐dinor‐8‐iso‐prostaglandin F2α concentrations were correlated with C‐reactive protein (CRP; r S = 0.491, P = .03), canine specific pancreatic lipase (Spec cPL; r S = 0.746, P = .002), and CAPS (r S = 0.603, P = .02). Conclusions and Clinical Importance Oxidant status is altered in dogs with naturally occurring AP, but the clinical relevance of this finding is unknown.

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.16535

Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

Materials and Methods: In total, 55 patients with acute pancreatitis and 47 healthy volunteers were included in the study. The study group was divided into three subgroups according to the computed tomography (CT) severity index. Group 1 consisted of patients with CT severity index score of 0-2, Group 2 consisted of patients with CT severity index of 3-6, and Group 3 consisted of patients with CT severity index 7-10. Total oxidant stress (TOS), total antioxidant stress (TAS), and oxidative stress index (OSI) were compared between study and control groups.

Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis

Fentanyl is a potent and short-acting narcotic analgesic which is used in the treatment of acute and chronic pain. Transdermal fentanyl have been widely used in the treatment of cronic pain. The side effects of transdermal fentanyl are similar to other opioids side effects. In this report we presented an 80 years old patient with lumbago who developed opiate toxicity after using one dose of fentanyl patch.

Can Using Only A Single Transdermal Fentanyl Patch Be Fatal

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Bülent Demir

Author Tools

Chat about Author

Papers

Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis

Can Using Only A Single Transdermal Fentanyl Patch Be Fatal