Buddhini Perera
Gunma University
12 Papers
65 Citations
Buddhini Perera is an academic researcher from Gunma University. The author has contributed to research in topics: Reperfusion injury & Angiogenesis. The author has an hindex of 9, co-authored 12 publications.
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Papers
MFG-E8 drives melanoma growth by stimulating mesenchymal stromal cell-induced angiogenesis and M2 polarization of tumor-associated macrophages
Kazuya Yamada,Akihiko Uchiyama,Akihito Uehara,Buddhini Perera,Sachiko Ogino,Yoko Yokoyama,Yuko Takeuchi,Mark C. Udey,Osamu Ishikawa,Sei-ichiro Motegi +9 more
TL;DR: It is suggested that MFG-E8 acts at two levels, by increasing VEGF and ET-1 expression in MSC and by enhancing M2 polarization of macrophages, to increase tumor angiogenesis.
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Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury
Akihiko Uchiyama,Kazuya Yamada,Buddhini Perera,Sachiko Ogino,Yoko Yokoyama,Yuko Takeuchi,Osamu Ishikawa,Sei-ichiro Motegi +7 more
TL;DR: The results suggest that BTX-A might have protective effects against ulcer formation after cutaneous I/R injury by enhancing angiogenesis and inhibiting hypoxia-induced cellular damage.
Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury.
Akihiko Uchiyama,Kazuya Yamada,Buddhini Perera,Sachiko Ogino,Yoko Yokoyama,Yuko Takeuchi,Osamu Ishikawa,Sei-ichiro Motegi +7 more
TL;DR: It is concluded that MFG-E8 may inhibit the formation of pressure ulcers induced by cutaneous I/R injury by regulating angiogenesis and inflammation.
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Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress.
Sei-ichiro Motegi,Akiko Sekiguchi,Akihiko Uchiyama,Akihito Uehara,Chisako Fujiwara,Sahori Yamazaki,Buddhini Perera,Hideharu Nakamura,Sachiko Ogino,Yoko Yokoyama,Ryoko Akai,Takao Iwawaki,Osamu Ishikawa +12 more
TL;DR: The results suggest that the injection of MSCs might protect against the development of PUs after cutaneous I/R injury by reducing vascular damage, oxidative cellularDamage, oxidative stress, ER stress, and apoptosis.
Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation.
Sei-ichiro Motegi,Yoko Yokoyama,Sachiko Ogino,Kazuya Yamada,Akihiko Uchiyama,Buddhini Perera,Yuko Takeuchi,Hiroshi Ohnishi,Osamu Ishikawa +8 more
TL;DR: In in vitro assays, melanin synthesis in human melanoma cells expressing SHp-2 with LS-associated mutations was higher than in cells expressing normal SHP-2, suggesting that LS- associated SHP -2 mutations might enhance melan in synthesis in melanocytes, and that the activation of Akt/mTOR signalling may contribute to this process.