Bu Dandan
Chinese Academy of Sciences
3 Papers
4 Citations
Bu Dandan is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Chirality (chemistry) & Chemistry. The author has an hindex of 1, co-authored 3 publications.
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Papers
Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction.
Juan Li,Jinhui Feng,Xi Chen,Jingyao Gong,Yunfeng Cui,Hongliu Zhang,Bu Dandan,Qiaqing Wu,Dunming Zhu +8 more
TL;DR: In this article, an engineered carbonyl reductase (M4) was obtained through structure-guided directed evolution of a SSCR from Sporobolomyces salmonicolor AKU4429, which showed 23.9fold enhancement of enzyme activity toward the model substrate 2-methyl-2-benzyl-1,3-cyclopentanedione, affording the (2S, 3S)-stereoisomer in >98% ratio.
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Highly Diastereoselective Synthesis of 2,2-Disubstituted Cyclopentane-1,3-diols via Stepwise Ketone Reduction Enabling Concise Chirality Construction.
Jingyao Gong,Jianjiong Li,Xi Chen,Hongliu Zhang,Liangyan Zhu,Bu Dandan,Qin Wang,Jinhui Feng,Qiaqing Wu,Dunming Zhu +9 more
TL;DR: This efficient and environment friendly method provides a practical approach to the synthesis of these chiral building blocks in single stereoisomeric form, demonstrating the power of biocatalysis in the concise chirality construction of complex chiral molecules.
4
Patent
Genetically engineered bacterium and application thereof to preparation of 9alpha,22-dihydroxy-23,24-bisnorcholest-4-ene-3-ketone
Ma Yanhe,Li Xuemei,Wu Qiaqing,Feng Jinhui,Zhu Dunming,Rui Zhang,Yu Wang,Zixiang Xu,Bu Dandan +8 more
- 18 Dec 2020
TL;DR: A genetically engineered bacterium was constructed by inactivating three genes kstd 1, kstd 2 and kstd 3 of 3sterone-delta-1-dehydrogenase in mycobacteria and overexpressing genes encoding acetyl coenzyme A acetyltransferase/thiolase and DNA binding protein, and can selectively generate 9alpha,22-dihydroxy-23,24-bisnorcholest-4-ene-3-ketone, thereby reducing byproduct 9-OH-AD as mentioned in this paper.