Bryce A. Schuler
Vanderbilt University Medical Center
4 Papers
19 Citations
Bryce A. Schuler is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Coronavirus & Lung. The author has an hindex of 3, co-authored 4 publications.
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Papers
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.
Bryce A. Schuler,A. Christian Habermann,Erin J. Plosa,Chase J. Taylor,Christopher S. Jetter,Nicholas M. Negretti,Meghan E. Kapp,John T. Benjamin,Peter Gulleman,David S. Nichols,Lior Z. Braunstein,Alice Hackett,Michael Koval,Susan H. Guttentag,Timothy S. Blackwell,Steven A. Webber,Nicholas E. Banovich,Jonathan A. Kropski,Jennifer M.S. Sucre +18 more
TL;DR: Combining single-cell RNA sequencing of developing mouse lung with temporally-resolved immunofluorescence in mouse and human lung tissue demonstrates the cellular spectrum infected by SARS-CoV-2 in lung epithelium and suggests that developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness.
Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung
Bryce A. Schuler,A. Christian Habermann,Erin J. Plosa,Chase J. Taylor,Christopher S. Jetter,Meghan E. Kapp,John T. Benjamin,Peter Gulleman,David S. Nichols,Lior Z. Braunstein,Michael Koval,Susan H. Guttentag,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Steven A. Webber,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski,Jennifer M.S. Sucre,Jennifer M.S. Sucre +21 more
TL;DR: Estimation of single-cell RNA sequencing of the developing mouse lung with temporally-resolved RNA-in-situ hybridization in mouse and human lung tissue suggests developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness.
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium.
Bryce A. Schuler,A. Christian Habermann,Erin J. Plosa,Chase J. Taylor,Christopher S. Jetter,Meghan E. Kapp,John T. Benjamin,Peter Gulleman,David S. Nichols,Lior Z. Braunstein,Alice Hackett,Michael Koval,Susan H. Guttentag,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Steven A. Webber,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski,Jennifer M.S. Sucre,Jennifer M.S. Sucre +22 more
TL;DR: Data demonstrate the cellular spectrum infected by SARS-CoV-2 in the lung epithelium, and suggest that developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness.
A Single Cell Atlas of Lung Development
Nicholas M. Negretti,Erin J. Plosa,John T. Benjamin,Bryce A. Schuler,A. Christian Habermann,Christopher S. Jetter,Peter Gulleman,Chase J. Taylor,David E. Nichols,Brittany K. Matlock,Susan H. Guttentag,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski,Jennifer M.S. Sucre,Jennifer M.S. Sucre +19 more
TL;DR: In this paper, a single cell RNA sequencing (scRNA-seq) time-series yielding 92,238 epithelial, endothelial, and mesenchymal cells across 8 time points from embryonic day 12 (E12) to postnatal day 14 (P14) in mice.
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