Bryan T. Phillips
University of Iowa
26 Papers
109 Citations
Bryan T. Phillips is an academic researcher from University of Iowa. The author has contributed to research in topics: Wnt signaling pathway & Asymmetric cell division. The author has an hindex of 13, co-authored 24 publications. Previous affiliations of Bryan T. Phillips include Texas A&M University & University of Wisconsin-Madison.
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Papers
Zebrafish fgf3 and fgf8 Encode Redundant Functions Required for Otic Placode Induction
TL;DR: The hypothesis that fgf3 and fgF8 cooperate during the latter half of gastrulation to induce differentiation of otic placodes is supported.
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A direct role for Fgf but not Wnt in otic placode induction.
TL;DR: It is demonstrated that localized misexpression of either Fgf3 or F gf8 is sufficient to induce ectopic otic placodes and vesicles, even in embryos lacking Wnt8, and it is proposed that FgF from the hindbrain then acts directly on preplacodal cells to induce otic differentiation.
An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in mis-patterning of the otic vesicle
TL;DR: The inner ear defects observed in val/val mutants appear to result from ectopic expression of fgf3 in the hindbrain, and data indicate that val normally represses fgF3 expression in r5 and r6, an interpretation further supported by the effects of misexpressing val in wild-type embryos.
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The tumor suppressor APC differentially regulates multiple β-catenins through the function of axin and CKIα during C. elegans asymmetric stem cell divisions
TL;DR: It is shown that APR-1 regulates SYS-1 levels in asymmetric stem cell division, in addition to its known role in lowering nuclear levels of WRM-1, and a model whereby Wnt signaling, through CKI&agr;, regulates the function of two distinct pools of APC, whereas the second pool stabilizes microtubules and promotes WRm-1 nuclear export.
Protein Aggregation and Disaggregation in Cells and Development.
TL;DR: A review of protein aggregation in biological systems can be found in this article, where the authors highlight the emerging roles of biomolecular condensates in early animal development, and disaggregation processing proteins that have recently been shown to play key roles in gametogenesis and embryogenesis.
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