Bryan McDonald
Salk Institute for Biological Studies
21 Papers
22 Citations
Bryan McDonald is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Biology & Cytotoxic T cell. The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Bryan McDonald include University of California, San Diego & La Jolla Institute for Allergy and Immunology.
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Papers
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors.
Shihao Xu,Omkar Chaudhary,Patricia Rodríguez-Morales,Xiaoli Sun,Dan Chen,Roberta Zappasodi,Roberta Zappasodi,Ziyan Xu,Ziyan Xu,Antonio Pinto,April Williams,Isabell Schulze,Isabell Schulze,Yagmur Farsakoglu,Siva Karthik Varanasi,Jun Siong Low,Wenxi Tang,Haiping Wang,Bryan McDonald,Victoria Tripple,Michael Downes,Ronald M. Evans,Nada A. Abumrad,Taha Merghoub,Jedd D. Wolchok,Maxim N. Shokhirev,Ping-Chih Ho,Joseph L. Witztum,Brinda Emu,Guoliang Cui,Guoliang Cui,Susan M. Kaech +31 more
TL;DR: In this paper, the authors examined how CD8+ tumor infiltrating lymphocytes (TILs) respond to lipids within the tumor microenvironment (TME) and found elevated concentrations of several classes of lipids in the TME and accumulation of these in CD8−/− TILs.
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Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
J. Justin Milner,Clara Toma,Zhaoren He,Nadia S. Kurd,Quynh P. Nguyen,Bryan McDonald,Lauren K. Quezada,Christella E. Widjaja,Deborah A. Witherden,John T. Crowl,Laura A Shaw,Gene W. Yeo,John T. Chang,Kyla D. Omilusik,Ananda W. Goldrath +14 more
TL;DR: These findings provide insight into the development and functional heterogeneity of Trm cells, which has implications for enhancing vaccination and immunotherapy approaches.
219
cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection
Chan-Wang J. Lio,Bryan McDonald,Mariko Takahashi,Rekha Dhanwani,Nikita Sharma,Jenny Huang,Elise Pham,Chris A. Benedict,Sonia Sharma +8 more
TL;DR: Primary human endothelial cells mount robust IFN-I responses to human CMV that are dependent upon cyclic GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3) signaling, demonstrating a pivotal role for the cGAS-STING pathway in the initial detection of CMV infection.
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Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models.
Joseph R Campbell,Bryan McDonald,Paul B Mesko,Nathan O. Siemers,Priti B. Singh,Mark J. Selby,Tim Sproul,Alan J. Korman,Logan M Vlach,Jeff Houser,Sharmila Sambanthamoorthy,Kai Lu,Sandra V. Hatcher,Jack Lohre,Renu Jain,Ruth Y. Lan +15 more
TL;DR: In this paper, the chemokine receptor CCR8 was proposed as an optimal tumor Treg target and selectively expressed on suppressive tumor T cells and minimally expressed on proinflammatory effector T cells (Teff).
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Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection.
Shilpi Verma,Daniela Weiskopf,Ankan Gupta,Bryan McDonald,Bjoern Peters,Alessandro Sette,Chris A. Benedict +6 more
TL;DR: The first two I-Ad-restricted CD4 T cell responses specific for mouse CMV (MCMV) epitopes are reported and a major histocompatibility complex class II (MHC-II) tetramer is used to characterize their phenotypes and functions.
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