Bryan J. Prazen
University of Washington
34 Papers
801 Citations
Bryan J. Prazen is an academic researcher from University of Washington. The author has contributed to research in topics: Gas chromatography & Two-dimensional chromatography. The author has an hindex of 22, co-authored 34 publications. Previous affiliations of Bryan J. Prazen include Seattle University.
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Papers
A guided tour of the Trans‐Proteomic Pipeline
Eric W. Deutsch,Luis Mendoza,David Shteynberg,Terry Farrah,Henry H N Lam,Natalie Tasman,Zhi Sun,Erik Nilsson,Brian S. Pratt,Bryan J. Prazen,Jimmy K. Eng,Daniel Martin,Alexey I. Nesvizhskii,Ruedi Aebersold +13 more
TL;DR: The full workflow of the TPP is described, along with an example on a sample data set, demonstrating that the setup and use of the tools are straightforward and well supported and do not require specialized informatic resources or knowledge.
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Standardization of Second-Order Chromatographic/Spectroscopic Data for Optimum Chemical Analysis
TL;DR: An objective technique to standardize second-order chromatographic−spectral data is both theoretically and experimentally developed and tested and corrects for retention time shifts that occur between the analysis of the calibration sample and “unknown” samples.
141
Comprehensive two-dimensional gas chromatography and chemometrics for the high-speed quantitative analysis of aromatic isomers in a jet fuel using the standard addition method and an objective retention time alignment algorithm
TL;DR: The generalized rank annihilation method (GRAM) is the chemometric technique used to resolve the overlapped GC x GC peaks, and using the retention time alignment algorithm, GRAM quantification accuracy and precision are improved by a factor of 4.
135
Trilinear chemometric analysis of two-dimensional comprehensive gas chromatography-time-of-flight mass spectrometry data.
TL;DR: This manuscript demonstrates how the selectivity of GC x GC/TOFMS combined with trilinear chemometric techniques such as tril inear decomposition (TLD) and parallel factor analysis (PARAFAC) results in a powerful analytical methodology.
106
Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection: analysis of amino acid and organic acid trimethylsilyl derivatives, with application to the analysis of metabolites in rye grass samples.
TL;DR: The real-time analysis capability of GC x GC/TOFMS for multidimensional metabolite analysis makes this technique well suited to the high-throughput analysis of metabolomic samples, especially compared to slower, stopped-flow type separation approaches.
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