Bryan Hurtle
University of Pittsburgh
6 Papers
Bryan Hurtle is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & G protein-coupled receptor. The author has an hindex of 1, co-authored 1 publications.
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Papers
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Jacob R. Mann,Amanda M. Gleixner,Jocelyn C. Mauna,Edward Gomes,Michael R. DeChellis-Marks,Patrick G. Needham,Katie E. Copley,Bryan Hurtle,Bede Portz,Noah J. Pyles,Lin Guo,Christopher B. Calder,Zachary P. Wills,Udai Bhan Pandey,Julia Kofler,Jeffrey L. Brodsky,Amantha Thathiah,James Shorter,Christopher J. Donnelly +18 more
TL;DR: The formation of pathologically relevant inclusions is driven by aberrant interactions between low-complexity domains of TDP-43 that are antagonized by RNA binding, and it is shown that aberrant phase transitions of cytoplasmic TTP are neurotoxic and that treatment with oligonucleotides composed of T DP-43 target sequences prevent inclusions and rescue neurotoxicity.
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Disrupting pathologic phase transitions in neurodegeneration
TL;DR: A review of the known mechanisms contributing to aberrant protein phase transitions in neurodegenerative diseases, focusing on tau and TDP-43 proteinopathies and outlining potential therapeutic strategies to regulate these pathologic events is provided in this paper .
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G protein‐biased GPR3 signaling induces glial activation and ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model
Amantha Thathiah,Yunhong Huang,Thais Rafael Guimarães,Nicholas Todd,Carolyn Ferguson,Kathryn M Weiss,Fiona R Stauffer,Breanne E. McDermott,Bryan Hurtle,Takashi Saito,Takaomi C. Saido,Matthew L. MacDonald,Sean P. Farris,Gregg E. Homanics +13 more
TL;DR: In this paper , a G protein−biased G protein-coupled receptor (GPCR)-dependent mouse model was proposed to attenuate AD-associated phenotypes while preserving the beneficial effects of GPR3−mediated G protein signaling.
Optogenetic model of tau aggregation for tauopathies
Bryan Hurtle,Christopher J. Donnelly,Xin Zhang,Amantha Thathiah +3 more
- 01 Dec 2022
TL;DR: In this paper , a photo-inducible system was proposed to control protein aggregation using photo-oligomerizable proteins that self-associate upon exposure to blue light.
Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD
Yuehua Zhu,Bryan Hurtle,Matthew Wright,Jocelyn C. Mauna,Marilyn Ngo,Cristian A. Bergmann,Jiazhen Xu,Jessica Merjane,Amanda M. Gleixner,Gabriela Grigorean,Wilfried Rossoll,Edward B. Lee,Evangelos Kiskinis,Maria Chikina,Christopher J. Donnelly +14 more