Bryan Hoglund
Hoffmann-La Roche
15 Papers
133 Citations
Bryan Hoglund is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Amplicon & Human leukocyte antigen. The author has an hindex of 6, co-authored 14 publications.
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Papers
Association of Parkinson disease with structural and regulatory variants in the HLA region.
William T. Wissemann,Erin M. Hill-Burns,Cyrus P. Zabetian,Stewart A. Factor,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Bryan Hoglund,Cherie Holcomb,Ryan J. Donahue,Glenys Thomson,Henry A. Erlich,Henry A. Erlich,Haydeh Payami,Haydeh Payami +13 more
TL;DR: It is shown here that several HLA-region SNPs that have since been associated with PD form two blocks tagged by rs3129882 and rs2395163, suggesting that HLA gene expression might influence PD and that noncoding SNPs in the HLA region can be associated with disease irrespective of HLA alleles.
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High throughput HLA genotyping using 454 sequencing and the Fluidigm Access Array™ System for simplified amplicon library preparation.
P. V. Moonsamy,Timothy C. Williams,Persia Bonella,Cherie Holcomb,Bryan Hoglund,Grantland Hillman,Damian Goodridge,Gregory S. Turenchalk,Lisbeth A. Blake,Derek A. Daigle,Birgitte B. Simen,Amy Hamilton,Andrew May,Henry A. Erlich,Henry A. Erlich +14 more
TL;DR: Next generation sequencing of exonic amplicons with the 454 genome sequence (GS) FLX System and Conexio Assign ATF 454 software provides high resolution, high throughput HLA genotyping for eight class I and class II loci.
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A multi-site study using high-resolution HLA genotyping by next generation sequencing.
Cherie Holcomb,Bryan Hoglund,Matthew W. Anderson,Lisbeth A. Blake,I. Böhme,Michael Egholm,Deborah Ferriola,Christian Gabriel,S. E. Gelber,Damian Goodridge,S. Hawbecker,R. Klein,Martha Ladner,Curt Lind,Dimitri S. Monos,Marcelo J. Pando,Johannes Pröll,David Sayer,Gudrun G. Schmitz-Agheguian,Birgitte B. Simen,B. Thiele,Elizabeth Trachtenberg,Dolly B. Tyan,Ralf Wassmuth,Shana White,Henry A. Erlich +25 more
TL;DR: It is concluded that clonal pyrosequencing using the GS FLX platform and CONEXIO ATF software allows reliable identification of HLA genotypes at high resolution.
Very high resolution single pass HLA genotyping using amplicon sequencing on the 454 next generation DNA sequencers: Comparison with Sanger sequencing.
Fumiko Yamamoto,Bryan Hoglund,Marcelo Fernandez-Vina,Dolly B. Tyan,Melinda Rastrou,T. Williams,P. V. Moonsamy,Damian Goodridge,Matthew W. Anderson,Henry A. Erlich,Cherie Holcomb +10 more
TL;DR: The results show that the amplicon-based VHR assay is robust and can replace current Sanger methodology and has the potential to provide even higher resolution HLA typing.
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Patent
Methods and Compositions for Very High Resolution Genotyping of HLA
Henry A. Erlich,Bryan Hoglund,Cherie Holcomb,P. V. Moonsamy +3 more
- 21 Aug 2013
TL;DR: In this article, a method of determining HLA genotype for HLA-A, HLAB, B, C, DQB1, DRB1, DBP1, B1, C2, C3, DPA1 and DPB1 was presented.
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