Brunilde Gril
National Institutes of Health
34 Papers
187 Citations
Brunilde Gril is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Brain metastasis & Breast cancer. The author has an hindex of 18, co-authored 29 publications. Previous affiliations of Brunilde Gril include Paris Descartes University & French Institute of Health and Medical Research.
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Papers
Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
Paul R. Lockman,Rajendar K. Mittapalli,Kunal S Taskar,Vinay Rudraraju,Brunilde Gril,Kaci A. Bohn,Chris E. Adkins,Amanda Roberts,Helen R. Thorsheim,Julie A. Gaasch,Suyun Huang,Diane Palmieri,Patricia S. Steeg,Quentin R. Smith +13 more
TL;DR: This work shows that the BTB remains a significant impediment to standard chemotherapeutic delivery and efficacy in experimental brain metastases of breast cancer, and new brain permeable drugs will be needed.
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Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Gonçalo Rodrigues,Gonçalo Rodrigues,Ayuko Hoshino,Ayuko Hoshino,Ayuko Hoshino,Candia M. Kenific,Irina Matei,Loïc Steiner,Loïc Steiner,Daniela Freitas,Han Sang Kim,Han Sang Kim,Peter R. Oxley,Ilana Scandariato,Irene Casanova-Salas,Jinxiang Dai,Chaitanya R. Badwe,Brunilde Gril,Milica Tesic Mark,Brian D. Dill,Henrik Molina,Haiying Zhang,Alberto Benito-Martin,Linda Bojmar,Yonathan Ararso,Katharine Offer,Quincey LaPlant,Weston Buehring,Huajuan Wang,Xinran Jiang,Tyler M. Lu,Yuan Liu,Joshua K. Sabari,Sandra J. Shin,Navneet Narula,Paula S. Ginter,Vinagolu K. Rajasekhar,John H. Healey,Etienne Meylan,Bruno Costa-Silva,Shizhen Emily Wang,Shahin Rafii,Nasser K. Altorki,Charles M. Rudin,David R. Jones,Patricia S. Steeg,Héctor Peinado,Cyrus M. Ghajar,Jacqueline Bromberg,Jacqueline Bromberg,Maria de Sousa,Maria de Sousa,David J. Pisapia,David Lyden +53 more
TL;DR: It is demonstrated that pre-conditioning the brain microenvironment with exosomes from brain metastatic cells enhances cancer cell outgrowth, and that targeting exosomal CEMIP could constitute a future avenue for the prevention and treatment of brain metastasis.
Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.
Brunilde Gril,Anurag N. Paranjape,Stephan Woditschka,Emily Hua,Emma L. Dolan,Jeffrey C. Hanson,Xiaolin Wu,Wojciech Kloc,Ewa Izycka-Swieszewska,Renata Duchnowska,Rafał Pęksa,Wojciech Biernat,Jacek Jassem,Naema Nayyar,Priscilla K. Brastianos,O Morgan Hall,Cody J. Peer,William D. Figg,Gary T. Pauly,Christina Robinson,Simone Difilippantonio,Emilie Bialecki,Philippe Metellus,Joel P. Schneider,Patricia S. Steeg +24 more
TL;DR: It is reported that experimental breast cancer brain metastases of low- and high permeability to a dextran dye exhibit distinct microenvironmental gene expression patterns, and neuroinflammatory astrocytic S1P3 modulates BTB permeability.
Brain metastases of breast cancer.
Diane Palmieri,Quentin R. Smith,Paul R. Lockman,Julie L. Bronder,Brunilde Gril,Ann F. Chambers,Robert J. Weil,Patricia S. Steeg +7 more
TL;DR: Central nervous system or brain metastases traditionally occur in 10-16% of metastatic breast cancer patients and are associated with a dismal prognosis, so new therapies with permeability for the blood-brain barrier are needed to counteract both types of tumor cells.
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Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
Manuel Valiente,Amanda E.D. Van Swearingen,Carey K. Anders,Amos Marc Bairoch,Adrienne Boire,Paula D. Bos,Diana M. Cittelly,Neta Erez,Gino B. Ferraro,Dai Fukumura,Brunilde Gril,Meenhard Herlyn,Sheri L. Holmen,Rakesh K. Jain,Johanna A. Joyce,Mihaela Lorger,Joan Massagué,Josh Neman,Nicola R. Sibson,Patricia S. Steeg,Frits Thorsen,Frits Thorsen,Leonie S. Young,Damir Varešlija,Adina Vultur,Adina Vultur,Frances Weis-Garcia,Frank Winkler +27 more
TL;DR: The coordinated effort of 19 laboratories to compile comprehensive information related to brain metastasis experimental models is presented, which represents the first of its class and includes information about the cell line, how tropism to the brain was established, and the behavior of each model in vivo.
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