Brune Vialet
University of Bordeaux
19 Papers
15 Citations
Brune Vialet is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Biology & G-quadruplex. The author has an hindex of 8, co-authored 12 publications. Previous affiliations of Brune Vialet include Centre national de la recherche scientifique & Université Bordeaux Segalen.
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Papers
Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications.
Sébastien Benizri,Sébastien Benizri,Sébastien Benizri,Arnaud Gissot,Arnaud Gissot,Arnaud Gissot,Andrew Martin,Brune Vialet,Brune Vialet,Brune Vialet,Mark W. Grinstaff,Philippe Barthélémy,Philippe Barthélémy,Philippe Barthélémy +13 more
TL;DR: Bioconjugated oligonucleotide-based agents have the potential to treat or cure almost any disease, and are one of the key therapeutic drug classes of the future as discussed by the authors.
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Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development.
Samir Amrane,Abdelaziz Kerkour,Abdelaziz Kerkour,Amina Bedrat,Amina Bedrat,Brune Vialet,Brune Vialet,Marie-Line Andreola,Marie-Line Andreola,Jean-Louis Mergny,Jean-Louis Mergny +10 more
TL;DR: Using NMR spectroscopy, the G4 topology adopted by a DNA sequence from HIV-PRO1 formed a stable two G-tetrad antiparallel G4 with an additional Watson-Crick CG base pair, which may be critical for HIV-1 gene expression and is potentially a novel target for anti-HIV-1 drug development.
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Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer.
Sara Karaki,Sébastien Benizri,Raquel Mejías,Virginie Baylot,Nicolas Branger,Tan Nguyen,Brune Vialet,Khalid Oumzil,Philippe Barthélémy,Palma Rocchi +9 more
TL;DR: It is shown that lipid‐modified ASO (LASOs) has improved penetration and efficiency in inhibiting TCTP expression in the absence of additional transfection agents, both in vitro and in vivo.
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Lipid oligonucleotides as a new strategy for tackling the antibiotic resistance.
Tina Kauss,Corinne Arpin,Léa Bientz,Phouc Vinh Nguyen,Brune Vialet,Sébastien Benizri,Philippe Barthélémy +6 more
TL;DR: The results support the concept that the self-delivery of oligonucleotide sequences via lipid conjugation may be extended to other antimicrobial drugs, which opens novel ways to struggle against the antibiotic resistance.
Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors
Cathy Staedel,Cathy Staedel,Christine Varon,Christine Varon,Phu Nguyen,Phu Nguyen,Brune Vialet,Brune Vialet,Lucie Chambonnier,Lucie Chambonnier,Benoit Rousseau,Isabelle Soubeyran,Serge Evrard,Franck Couillaud,Franck Couillaud,Fabien Darfeuille,Fabien Darfeuille +16 more
TL;DR: MicroRNA silencing by 8-mer seed-targeting LNAs appears a valuable approach for both loss-of-function studies aimed at elucidating microRNA functions and for microRNA-based therapeutic strategies.
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