Bruce Sun

TL;DR: It is demonstrated that automated reprogramming and the pooled selection of polyclonal pluripotent cells results in high-quality, stable iPSCs, which display less line-to-line variation than either manually produced lines or lines produced through automation followed by single-colony subcloning.

TL;DR: Using human mitochondrial replacement stem cell lines, it is shown that, even though the low levels of heteroplasmy introduced into human oocytes by mitochondrial carryover during nuclear transfer often vanish, they can sometimes instead result in mtDNA genotypic drift and reversion to the original genotype.

TL;DR: This article found evidence of a coregulated network of transcription factors that mediates glucocorticoid hyper-responsivity in post-traumatic stress disorder (PTSD) using human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons and peripheral blood mononuclear cells (PBMCs).

TL;DR: Using serum-free embryoid bodies generated from human inducible pluripotent stem cells (iPSCs), it is demonstrated that these interneuron progenitors exhibit morphological, immunocytochemical, and electrophysiological hallmarks of developing cortical interneurons.