Bruce M. Spiegelman
Harvard University
447 Papers
3.9K Citations
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Biology. The author has an hindex of 179, co-authored 434 publications. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
Chat about Author
Papers
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
TL;DR: In this paper, an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that directs high-level adipocyte-specific gene expression in both cultured cells and transgenic mice was identified.
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
TL;DR: The data indicate that AMPK phosphorylation of PGC-1α initiates many of the important gene regulatory functions of AMPK in skeletal muscle.
Metabolic control through the PGC-1 family of transcription coactivators.
TL;DR: This work has shown that the PGC-1 coactivators play a critical role in the maintenance of glucose, lipid, and energy homeostasis and are likely involved in the pathogenic conditions such as obesity, diabetes, neurodegeneration, and cardiomyopathy.
2.2K
Adipocytes as regulators of energy balance and glucose homeostasis
TL;DR: Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways as discussed by the authors.
2.2K
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
Julie St-Pierre,Stavit Drori,Marc Uldry,Jessica M. Silvaggi,James Rhee,Sibylle Jäger,Christoph Handschin,Kangni Zheng,Jiandie D. Lin,Wenli Yang,David Simon,Robert M. Bachoo,Robert M. Bachoo,Bruce M. Spiegelman +13 more
TL;DR: Increase in PGC-1alpha levels dramatically protects neural cells in culture from oxidative-stressor-mediated death, providing a potential target for the therapeutic manipulation of these important endogenous toxins.
2.2K