Brooke Bonsack
University of South Florida
17 Papers
9 Citations
Brooke Bonsack is an academic researcher from University of South Florida. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 6, co-authored 16 publications.
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Papers
Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury
Brooke Bonsack,Sydney Corey,Alex Shear,Matt Heyck,Blaise Cozene,Nadia Sadanandan,Henry Zhang,Bella Gonzales-Portillo,Michael Sheyner,Cesar V. Borlongan +9 more
TL;DR: This review summarizes the classification of cell death in ABI and discusses the prominent role of inflammation, and considers the efficacy of bone marrow–derived mesenchymal stem/stromal cell (BM‐MSC) transplantation as a therapy for these injuries.
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Cell therapy for central nervous system disorders: Current obstacles to progress.
Takao Yasuhara,Satoshi Kawauchi,Kyohei Kin,Jun Morimoto,Masahiro Kameda,Tatsuya Sasaki,Brooke Bonsack,Chase Kingsbury,Naoki Tajiri,Cesario V. Borlongan,Isao Date +10 more
TL;DR: The milestone achievements of cell therapy for central nervous system disorders, with equal consideration on the present translational obstacles for clinic application, are described.
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Progress in progestin-based therapies for neurological disorders.
Regine Sitruk-Ware,Brooke Bonsack,Roberta Diaz Brinton,Michael Schumacher,Narender Kumar,Jea-Young Lee,Vanessa Castelli,Sydney Corey,Alexandreya B. Coats,Nadia Sadanandan,Bella Gonzales-Portillo,Matt Heyck,Alex Shear,Cozene Blaise,Henry Zhang,Michael Sheyner,Julián García-Sánchez,Lisset Navarro,Martine El-Etr,Alejandro F. De Nicola,Cesario V. Borlongan +20 more
TL;DR: This article assess the scientific and clinical progress over decades of research into progesterone, progestins, and Nestorone as neuroprotective agents in MS, ALS, SCI, and stroke.
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Brief overview: Protective roles of astrocyte-derived pentraxin-3 in blood-brain barrier integrity
Brooke Bonsack,Mia C Borlongan,Eng H. Lo,Ken Arai +3 more
- 01 Jul 2019
TL;DR: Evidence was found to suggest that astrocytes play a key role in stroke by expressing PTX3, which, in turn, enhances endothelial tightness, increases tight junction proteins, and inhibits vascular endothelial growth factor.
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Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke
Sydney Corey,Brooke Bonsack,Matt Heyck,Alex Shear,Nadia Sadanandan,Henry Zhang,Cesar V. Borlongan +6 more
- 22 Jan 2020
TL;DR: Experimental therapies employing stem cells employing stem cell transplants support their potential for neuroprotection and neuroregeneration after hemorrhagic stroke, and largely posit stem cells as safe and potent biologics for stroke, specifically owing to their mode of action for sequestering neuroinflammation and promoting Neuroregenerative processes.
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