Brock Humphries
University of Michigan
24 Papers
7 Citations
Brock Humphries is an academic researcher from University of Michigan. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 11, co-authored 24 publications.
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Papers
Integrin α5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway
Yajuan Xiao,Yunfei Li,Hua Tao,Brock Humphries,Aimin Li,Yiguo Jiang,Chengfeng Yang,Rongcheng Luo,Zhishan Wang +8 more
TL;DR: It is found that microRNA-205 expression level is extremely low in basal mesenchymal-like highly migratory and invasive TNBC cells and mechanistic studies indicated that ITGA5 down-regulation by miR-205 re-expression impairs TNBC cell metastatic traits by inhibiting the Src/Vav2/Rac1 pathway.
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MiR-205 Dysregulations in Breast Cancer: The Complexity and Opportunities.
TL;DR: It is concluded that miR-205-5p is an important tumor suppressive miRNA capable of inhibiting the growth and metastasis of human breast cancer, especially triple negative breast cancer.
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Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation
Zhishan Wang,Jianjun Wu,Brock Humphries,Kazuya Kondo,Yiguo Jiang,Xianglin Shi,Chengfeng Yang +6 more
TL;DR: It is found that chronic Cr(VI) exposure causes epigenetic dysregulation as evidenced by the increased levels of histone H3 repressive methylation marks and the related histone‐lysing methyltransferases (HMTases), and that increased expression of HMTases plays a causal role in Cr( VI)‐induced CSC‐like property and cell transformation.
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Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses.
TL;DR: Although the majority of data indicates an oncogenic role of Rho GTPases, tumor suppressor functions of RHo GTPase have also been revealed, suggesting a context and cell-type specific function for RhoGTPases in cancer.
Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis.
Yu Chih Chen,Saswat Sahoo,Riley Brien,Seungwon Jung,Brock Humphries,Woncheol Lee,Yu Heng Cheng,Zhixiong Zhang,Kathryn E. Luker,Max S. Wicha,Gary D. Luker,Euisik Yoon,Euisik Yoon +12 more
TL;DR: Using a microfluidic device that enriches migratory breast cancer cells with enhanced capacity for tumor formation and metastasis, genes differentially expressed in migratory cells are identified by high-throughput single-cell RNA-sequencing.
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