Brittany Staines
University of Pittsburgh
7 Papers
8 Citations
Brittany Staines is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Coronavirus. The author has an hindex of 3, co-authored 4 publications.
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Papers
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study.
Matthew K Hensley,William Bain,William Bain,Jana L. Jacobs,Sham Nambulli,Urvi M. Parikh,Anthony R. Cillo,Brittany Staines,Amy Heaps,Michele D. Sobolewski,Linda J. Rennick,Bernard J.C. Macatangay,Cynthia Klamar-Blain,Georgios D Kitsios,Barbara Methé,Ashwin Somasundaram,Tullia C. Bruno,Carly Cardello,Feng Shan,Creg J. Workman,Prabir Ray,Anuradha Ray,Janet S. Lee,Rahil Sethi,William E. Schwarzmann,Mark S. Ladinsky,Pamela J. Bjorkman,Dario A. A. Vignali,W. Paul Duprex,Mounzer Agha,John W. Mellors,Kevin D. McCormick,Alison Morris,Ghady Haidar +33 more
TL;DR: In this article, a chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months.
SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes.
Jana L. Jacobs,William Bain,Asma Naqvi,Brittany Staines,Priscila M. S. Castanha,Haopu Yang,Haopu Yang,Valerie F. Boltz,Simon M. Barratt-Boyes,Ernesto T. A. Marques,Stephanie L. Mitchell,Barbara Methé,Tolani F. Olonisakin,Ghady Haidar,Thomas W. Burke,Elizabeth Petzold,Thomas N. Denny,Christopher W. Woods,Christopher W. Woods,Bryan J. McVerry,Janet S. Lee,Simon C. Watkins,Claudette M. St. Croix,Alison Morris,Mary F. Kearney,Mark S. Ladinsky,Pamela J. Bjorkman,Georgios D Kitsios,John W. Mellors +28 more
TL;DR: In this article, SARS-CoV-2 vRNA was detected in plasma of 100%, 52.6%, and 11.1% of ICU, non-ICU, and outpatients respectively.
IgG response to SARS-CoV-2 and seasonal coronaviruses contributes to complement overactivation in severe COVID-19 patients.
Priscila M. S. Castanha,Dylan J Tuttle,Georgios D Kitsios,Jana L. Jacobs,Ulisses Braga-Neto,Matthew Duespohl,Sanjay Rathod,Michelle Marti,Sarah E Wheeler,Asma Naqvi,Brittany Staines,John W. Mellors,Alison Morris,Bryan J. McVerry,Faraaz Ali Shah,Caitlin Schaefer,Bernard J.C. Macatangay,Barbara A. Methé,Christian A. Fernandez,Simon M. Barratt-Boyes,Donald Burke,Ernesto T. A. Marques +21 more
TL;DR: Findings indicate that early, non-neutralizing IgG responses may play a key role in complement overactivation in severe COVID-19, and underscores the urgent need to develop therapeutic strategies to modify complement over activation in CO VID-19 patients.
Associations of HIV persistence, cigarette smoking, inflammation, and pulmonary dysfunction in people with HIV on antiretroviral therapy
Joshua C. Cyktor,Shulin Qin,Brittany Staines,Mehdi Nouraie,Meghan Fitzpatrick,Cathy Kessinger,Rebecca S. DeSensi,Laurence Huang,Charles R. Rinaldo,Lawrence A. Kingsley,Phyllis C. Tien,John W. Mellors,Alison Morris +12 more
TL;DR: Investigation of the relationship between measures of HIV persistence with antiretroviral therapy and cigarette smoking, systemic markers of inflammation, and pulmonary function found HIV DNA, CA-RNA, and plasma HIV RNA were not significantly associated with any measure of pulmonary function or inflammation.
Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019
Priscila M. S. Castanha,Dylan J Tuttle,Georgios D Kitsios,Jana L. Jacobs,Ulisses Braga-Neto,Matthew Duespohl,Sanjay Rathod,Michelle Marti,Sarah E Wheeler,Asma Naqvi,Brittany Staines,John W. Mellors,Alison Morris,Bryan J. McVerry,Faraaz Ali Shah,Caitlin Schaefer,Bernard J.C. Macatangay,Barbara Methé,Christian A. Fernandez,Simon M. Barratt-Boyes,Donald Burke,Ernesto T. A. Marques +21 more
TL;DR: It is shown that plasma levels of C1q and circulating immune complexes were markedly increased in patients with severe COVID-19 and correlated with higher immunoglobulin (Ig) G titers, greater complement activation, and higher disease severity score, which indicates that early, nonneutralizing IgG responses may play a key role in complement overactivation in severe CO VID-19.