Britta Laube
Leipzig University
5 Papers
46 Citations
Britta Laube is an academic researcher from Leipzig University. The author has contributed to research in topics: Hepatocyte & Bioreactor. The author has an hindex of 3, co-authored 5 publications.
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Papers
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures.
Rolf Gebhardt,Jan G. Hengstler,Dieter Müller,R. Glöckner,Peter Buenning,Britta Laube,Eva Schmelzer,Martina Ullrich,Dietmar Utesch,Nicola J. Hewitt,M. Ringel,Beate Reder Hilz,Augustinus Bader,Angelika Langsch,Thomas Koose,Hans-Jörg Burger,Jochen Maas,Franz Oesch +17 more
TL;DR: Five in vitro systems with hepatocytes in suspension, perifusion culture systems, liver slices, co-culture systems of hepatocytes with intestinal bacteria, and 96-well plate bioreactors are discussed, which offer the possibility of high throughput and automatization.
275
Enzyme induction in cryopreserved human hepatocyte cultures.
Sabine Kafert-Kasting,Krassimira Alexandrova,Marc Barthold,Britta Laube,Gerhard Friedrich,Lubomir Arseniev,Jan G. Hengstler +6 more
TL;DR: Human hepatocytes cryopreserved on collagen gels show a clear induction of CYP3A4 by rifampicin, although the basal activities are reduced compared to non-frozen cells.
37
Patent
Cryopreservation of hepatocytes
Arseniev Lubomir,Alexandrova Krassimira,Barthold Marc,Kafert-Kasting Sabine,Britta Laube +4 more
- 03 Nov 2006
TL;DR: In this article, the authors described methods for preparing hepatic cells for cryopreservation, to methods for the cryopreervation of isolated hepatic cell, and to producing a culture of frozen isolated cells.
8
Determination of Testosterone Metabolites in Rat Hepatocytes with and without Cryopreservation by On-Line SPE Column-Switching LC and MS Detection
Gerhard Friedrich,Thorsten Rose,Alexander Wawkuschewski,Sabine Kafert-Kasting,Britta Laube,Lubomir Arseniev,Klaus Rissler +6 more
TL;DR: All six testosterone metabolites, namely 2α-OHT, 2β-O HT, 6α-oHT, 6β- OHT, 7α- oHT and 16α-WHT, could be sufficiently separated from each other and thus an unequivocal assignment to the individual structures was achieved.
2
Patent
Kryokonservierung von hepatocyten
Arseniev Lubomir,Alexandrova Krassimira,Barthold Marc,Kafert-Kasting Sabine,Britta Laube +4 more
- 03 Nov 2006
TL;DR: In this article, the authors find verfahren zur Praparation von Leberzellen fur die Kryokonservierung, Verfahnd zur Kryokonstrategies isolierter leberzelle and Verf Fahndung zur Herstellung einer Kultur kryokonervierter isolateierter LeberZellen.