Britta Burkhardt
University of Tübingen
11 Papers
73 Citations
Britta Burkhardt is an academic researcher from University of Tübingen. The author has contributed to research in topics: Oxidative stress & Hepatocyte. The author has an hindex of 7, co-authored 11 publications.
Chat about Author
Papers
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity
Lilianna Schyschka,J. J. Martínez Sánchez,Zhiyong Wang,Britta Burkhardt,U. Müller-Vieira,Katrin Zeilinger,Anastasia Bachmann,S. Nadalin,Georg Damm,Andreas K. Nussler +9 more
TL;DR: 3D cultures cultured in 3D preserve certain metabolic functions that have closer resemblance to the in vivo situation than PHH in 2D cultures, which will allow for a more accurate hepatotoxicity prediction in in vitro models in the future.
119
3D Cultivation Techniques for Primary Human Hepatocytes.
Anastasia Bachmann,Matthias Moll,Eric Gottwald,Cordula Nies,Roman Zantl,Helga Wagner,Britta Burkhardt,Juan J. Martínez Sánchez,Ruth Ladurner,Wolfgang E. Thasler,Georg Damm,Andreas K. Nussler +11 more
TL;DR: The benefits and drawbacks of different 3D microfluidic devices are discussed, which could be achieved by their simplification and their compatibility with high-throughput, as both aspects are of major importance for a user-friendly device.
52
Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI
Victoria Kegel,Elisa Pfeiffer,Britta Burkhardt,Jia L. Liu,Katrin Zeilinger,Andreas K. Nussler,Daniel Seehofer,Georg Damm +7 more
TL;DR: KC were able to detect hepatocyte stress/damage and to transmit a donor- and compound-dependent immune response via cytokine production in a newly established in vitro liver model of DILI.
Long-term culture of primary hepatocytes: new matrices and microfluidic devices
Britta Burkhardt,Juan José Martinez-Sanchez,Anastasia Bachmann,Ruth Ladurner,Andreas K. Nussler +4 more
TL;DR: Recently developed hydrogels and scaffolds for 3D culture of hepatocytes are presented, which aim at preserving hepatic morphology and functionality for up to 4 weeks in culture, and major benefits and drawbacks of microfluidic devices for in vitro hepatotoxicity screening are discussed.
23