Bridgid E. Hast
University of North Carolina at Chapel Hill
5 Papers
40 Citations
Bridgid E. Hast is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 5, co-authored 5 publications.
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Papers
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination
Bridgid E. Hast,Dennis Goldfarb,Kathleen M. Mulvaney,Michael A. Hast,Priscila F. Siesser,Feng Yan,D. Neil Hayes,Michael B. Major +7 more
TL;DR: It is found that the dipeptidyl peptidase 3 (DPP3) protein binds KEAP1 via an "ETGE" motif to displaceNRF2, thus inhibiting NRF2 ubiquitination and driving NRF1-dependent transcription and suggesting that "ET GE"-containing proteins such as DPP3 contribute to NRF 2 activity in cancer.
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Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53
Shelly Sorrells,Seth Carbonneau,Erik B. Harrington,Aye T. Chen,Bridgid E. Hast,Brett Milash,Ujwal J. Pyati,Michael B. Major,Yi Zhou,Leonard I. Zon,Rodney A. Stewart,A. Thomas Look,Cicely A. Jette +12 more
TL;DR: A new gene regulating a dosage-sensitive response to DNA DSBs during embryonic development is identified, which causes a severe sensitivity of zebrafish embryonic neurons to IR–induced apoptosis and is required for the proper development of the central nervous system.
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.
TL;DR: Comparison of three popular algorithms, HGSCore, CompPASS, and SAINT, revealed complementarity in their classification accuracies, which is supported by their divergent scoring strategies.
Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
Bridgid E. Hast,Erica W. Cloer,Dennis Goldfarb,Heng Li,Priscila F. Siesser,Feng Yan,Vonn Walter,Ning Zheng,D. Neil Hayes,Michael B. Major +9 more
TL;DR: Cell-based and in vitro biochemical analyses demonstrated that despite its inability to suppress NRF2 activity, the R320Q "superbinder" mutant maintained the ability to ubiquitinate NRF3 and provide new insight into KEAP1 mechanics.
Regulation of endocytosis via the oxygen-sensing pathway
Yi Wang,Olga Roche,Mathew S Yan,Greg Finak,Andrew Evans,Andrew Evans,Julie L Metcalf,Bridgid E. Hast,Sara C. Hanna,Bill Wondergem,Kyle A. Furge,Meredith S. Irwin,William Y. Kim,Bin Tean Teh,Sergio Grinstein,Morag Park,Philip A. Marsden,Michael Ohh +17 more
TL;DR: Findings reveal a general role of the oxygen-sensing pathway in endocytosis and support a model in which tumor hypoxia or oncogenic activation of HIF prolongs RTK-mediated signaling by delaying endocyTosis-mediated deactivation of receptors.