Bridget L. Morse
University of Western Ontario
6 Papers
26 Citations
Bridget L. Morse is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Trimethylamine N-oxide & Pharmacogenomics. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Bridget L. Morse include London Health Sciences Centre.
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Papers
Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events
Richard B. Kim,Bridget L. Morse,Ognjenka Djurdjev,Mila Tang,Norman Muirhead,Brendan J. Barrett,Daniel T. Holmes,François Madore,Catherine M. Clase,Claudio Rigatto,Adeera Levin,Mohsen Agharazii,Joanne Blouin,Ayub Akbarii,Judy Cheesman,Jennilea Courtney,Sabrina Hamer,Edita Delic,Valerie Cronin,Paul E. Barre,Jeffrey Golden,Elizabeth Langille,Sandra Adams,Janet Morgan,Catherine M. Clase,Cathy Moreau,Susan Cooper,Brian R. Forzley,Susan Caron,Shauna Granger,Susan Valley,Helen Sather,Serge Cournoyer,Lorraine Menard,Michèle Roy,Hélène Skidmore,Dolores Beaudry,Janis Dionne,Josephine Chow,Valla Sahraei,Sandra Donnelly,Niki Dacouris,Rosa Marticorena,Brenda R. Hemmelgarn,Sharon Gulewich,Troy Hamilton,Paul Keown,Nadia Zalunardo,Daniel Rogers,Reena Tut,Matthew Paquette,Rossitta Yung,Nancy Ferguson,Helen H. L. Chiu,Kathleen Carlson,Lina Sioson,Taylor Perry,Zainab Sheriff,Naama Rozen,Charmaine Lok,Michelle Cross,Cathy Forrester,Alexandra Cotoi,Manon Maltais,Louise Moist,Kerri Gallo,Sarah Langford,Leah Slamen,Danielle Cram,Mary Jeanne Edgar,Taylor Gray,Cameron Edgar,Karen Groeneweg,Eileen McKinnon,Erin McRae,Kyla Blackie,Bharat Nathoo,Kimmy Lau,Malvinder S. Parmar,Sylvie Gelinas,Martine Leblanc,Lucie Lépine,Dolores Friesen,Steven D. Soroka,Susan Fleet,Jeanette Squires,Siva Thanamayooran,Michael Binder,Christine Hines,Brenda McNeil,Patrice McDougall,Joy Howard,Deborah Gillis,Kathleen Hines,Sheldon W. Tobe,Mary Chessman,Nancy Perkins,Martha Agelopoulos,Stacey Knox,Tiffany Richards,Marcello Tonelli,Susan Szigety,Dawn Opgenorth,Karen Yeates,Karen Mahoney +104 more
TL;DR: The results suggest that TMAO may represent a new potentially modifiable CV risk factor for CKD patients, and further studies are needed to determine sources of variability and if lowering of TmaO reduces CV risk in CKD.
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Trimethylamine- N -oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
Aze Wilson,Wendy A. Teft,Bridget L. Morse,Yun-Hee Choi,Sarah Woolsey,Marianne K. DeGorter,Robert A. Hegele,Rommel G. Tirona,Richard B. Kim +8 more
TL;DR: Decreased TMAO levels are seen in IBD compared to a non-IBD population and may have potential as a biomarker to support IBD diagnosis as well as to assess disease activity in UC.
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters.
Wendy A. Teft,Bridget L. Morse,Brenda F. Leake,Aze Wilson,Sara E. Mansell,Robert A. Hegele,Richard H. Ho,Richard B. Kim,Richard B. Kim +8 more
TL;DR: After screening a large array of uptake transporters, it is shown organic cation transporter 2 (OCT2) is the key transporter for TMAO cellular uptake, suggesting the importance of Oct2 in facilitating the uptake of T MAO into renal tubular cells in vivo.
Is personalized medicine a dream or a reality
Bridget L. Morse,Richard B. Kim +1 more
TL;DR: It is shown, for a number of drugs in clinical use, that genomics-guided treatment options not only are becoming feasible but are also on the cusp of showing superiority in terms of clinical outcomes as well as cost-benefit.
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