The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.

Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes

The present invention relates to compositions and methods for the treatment of diseases and conditions, including ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against bioactive lipids and which are capable of decreasing the effective concentration of the bioactive lipids. In some embodiments, the immune-derived moiety is a monoclonal antibody that is reactive against sphinxine- 1 -phosphate (SlP) or lysophosphophatidic acid (LPA).

Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions

An implantable medical device is disclosed comprising a high-density lipoprotein (HDL), recombinant HDL, high-density lipoprotein mimics (HDLm), or a combination thereof. Method are also disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

High-density lipoprotein coated medical devices

Compositions, methods and kits for diagnosing and treating cancer are provided Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL) Such compositions may be administered to a mammal afflicted with cancer Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease SPL polypeptides, polynucleotides and antibodies are also provided

Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor

Methods and compositions are disclosed that are useful for the prevention and/or treatment of cancer, angiogenesis, and inflammation. The beneficial effects of the compositions and methods are achieved through the use of pharmaceutical compositions that include agents that bind sphingolipids or sphingolipid metabolites. In one embodiment the agent is an antibody or antibody derivative. In some embodiments, the agent is a receptor of a sphingolipid or a sphingolipid metabolite. Also disclosed are methods for identifying and isolating therapeutic agents.

Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation

The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.

Sphingosine kinase enzyme

A screening method for identifying a therapeutic candidate for a coronary heart disease or an inflammatory condition is disclosed. The screening method tests for the presence or absence of an effect by a putative therapeutic agent on a component of a sphingosine kinase signaling pathway.

Screening method for an agent having an effect on a sphingosine kinase signaling pathway

The present invention relates generally to a method of modulating cellular activity and agents useful for same. More particularly, the present invention contemplates a method of modulating endothelial cell activity and even more particularly endothelial cell adhesion molecule expression. Most particularly, the present invention provides a method of treating coronary heart disease by preventing or reducing endothelial cell adhesion molecule expression.

A method of modulating cellular activity

The invention relates to detection of sphingosine kinase activity and sphingosine kinase agonist or antagonist activity.

Detection of sphingosine kinase activity and sphingosine kinase agonist or antagonist activity

La presente invention concerne generalement des molecules proteiques et leurs derives, analogues, equivalents chimiques et mimetiques pouvant moduler l'activite cellulaire et, en particulier, moduler l'activite cellulaire via la modulation de la transduction de signal. Elle concerne plus particulierement une sphingosine kinase humaine ainsi que ses derives, analogues, equivalents chimiques et mimetiques. Elle concerne aussi des sequences geniques codant pour ces molecules proteiques et leurs derives, analogues, equivalents chimiques et mimetiques. Les molecules de la presente invention sont utiles dans un domaine d'applications therapeutiques, prophylactiques et de diagnostics.

Enzyme sphingosine kinase

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