Brian W. Busser
National Institutes of Health
25 Papers
406 Citations
Brian W. Busser is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Enhancer & Transcription factor. The author has an hindex of 16, co-authored 25 publications. Previous affiliations of Brian W. Busser include University of Pennsylvania & Brigham and Women's Hospital.
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Papers
Expression-guided in silico evaluation of candidate cis regulatory codes for Drosophila muscle founder cells.
Anthony A. Philippakis,Brian W. Busser,Stephen S. Gisselbrecht,Fangxue Sherry He,Fangxue Sherry He,Beatriz Estrada,Alan D. Michelson,Martha L. Bulyk +7 more
TL;DR: The present analyses suggest that a modified form of this cis regulatory code applies to only a subset of founder cell genes, those whose gene expression responds to specific genetic perturbations in a similar manner to the gene on which the original model was based.
Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance
TL;DR: It is shown that a diverse CD4+ T cell repertoire is required to generate a sustained effector B cell response capable of mediating systemic autoimmunity and combined two limited repertoires of T cells provides sufficient CD4- T cell diversity to drive antinuclear Ab production.
Toward a systems-level understanding of developmental regulatory networks.
TL;DR: In this article, integrative genomics approaches for elucidating developmental transcriptional regulatory networks (TRNs) are discussed, with an emphasis on those involved in Drosophila mesoderm development and mammalian embryonic stem cell maintenance and differentiation.
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Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors
Xianmin Zhu,Shaad M. Ahmad,Anton Aboukhalil,Anton Aboukhalil,Brian W. Busser,Yongsok Kim,Terese Tansey,Adrian D. Haimovich,Neal Jeffries,Martha L. Bulyk,Martha L. Bulyk,Alan M. Michelson +11 more
TL;DR: It is established that different cell-specific members of a TF family regulate the activity of a single enhancer in distinct spatiotemporal domains, and how individual binding motifs for a TF class can differentially influence gene expression is demonstrated.
Antigen presentation by keratinocytes directs autoimmune skin disease.
TL;DR: Cutaneous immunopathology can be directed through antigen presentation by tissue-resident keratinocytes to autoreactive TCR Tg CD4+ cells to treat inflammatory skin disease with mononuclear infiltrates, induction of MHC class II expression on keratin cells, and T helper 1 cytokines.
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