Brian Vukusic
Toronto Western Hospital
6 Papers
71 Citations
Brian Vukusic is an academic researcher from Toronto Western Hospital. The author has contributed to research in topics: Antigen & T-cell receptor. The author has an hindex of 4, co-authored 6 publications.
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Papers
Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells.
Lorraine Poplonski,Brian Vukusic,Judy Pawling,Susan Clapoff,John C. Roder,N. Hozumi,Joan E. Wither +6 more
TL;DR: Results indicate that, despite evidence for clonal inactivation of many BI‐ specific T cells in BI‐transgenic mice, loss of tolerance results from activation of low‐affinity antigen‐specific T cells that appear to have escaped this process.
36
•Journal Article
Autoimmunity Develops in Lupus-Prone NZB Mice Despite Normal T Cell Tolerance
Joan E. Wither,Brian Vukusic +1 more
TL;DR: Comparison of tolerance in NZB and BALB/c BI-transgenic mice clearly demonstrated that NZB T cells were at least as tolerant to BI as BALb/c T cells, and backcrossed a transgene encoding bovine insulin (BI) onto the NZB background indicated that a generalized T cell tolerance defect does not underlie the autoimmune disease inNZB mice.
21
Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response
Brian Vukusic,Lorraine Poplonski,Laurie Phillips,Judy Pawling,Terry L. Delovitch,Nobumichi Hozumi,Joan E. Wither +6 more
TL;DR: It is demonstrated that both MHC and background gene heterozygosity affect TCR repertoire selection, suggesting that the variable expression of autoimmune disease in individuals with a susceptible MHC allele may result, in part, from variability in the TCR repertoires introduced by this heter chromosome.
13
•Journal Article
The Orientation and Nature of the Interaction Between Beef Insulin-Specific TCRs and the Insulin/Class II MHC Complex
Joan E. Wither,Brian Vukusic +1 more
TL;DR: It is demonstrated that all beef insulin-specific TCR have the same orientation on the insulin/Ad complex, such that the alpha-chain interacts with the carboxyl-terminal region of the A beta(d) alpha-helix, and the beta-chain complementarity-determining region 3 interacts with that observed for crystallized TCR-peptide/class I complexes.
2
Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage to Nba2.
TL;DR: It is proposed that immune mechanisms leading to polyclonal B cell activation and up‐regulation of costimulatory molecules in these mice play a central role in the loss of tolerance that leads to production of pathogenic autoantibodies.