Brian S. Kim
Washington University in St. Louis
216 Papers
484 Citations
Brian S. Kim is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Atopic dermatitis. The author has an hindex of 38, co-authored 167 publications. Previous affiliations of Brian S. Kim include University of Southern California & University of British Columbia.
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Papers
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
Jonathan R. Brestoff,Brian S. Kim,Steven A. Saenz,Rachel R. Stine,Laurel A. Monticelli,Gregory F. Sonnenberg,Joseph J.C. Thome,Donna L. Farber,Kabirullah Lutfy,Patrick Seale,David Artis +10 more
TL;DR: It is demonstrated that decreased ILC2 responses in WAT are a conserved characteristic of obesity in humans and mice, and methionine-enkephalin peptides that can act directly on adipocytes to upregulate UCP1 expression in vitro and that promote beiging in vivo are found.
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
Landon K. Oetjen,Madison R. Mack,Jing Feng,Timothy M. Whelan,Haixia Niu,Changxiong J. Guo,Sisi Chen,Anna M. Trier,Amy Z. Xu,Shivani V. Tripathi,Jialie Luo,Xiaofei Gao,Lihua Yang,Samantha L. Hamilton,Peter L. Wang,Jonathan R. Brestoff,Richard Brasington,Andras Schaffer,Frank Brombacher,Chyi-Song Hsieh,Robert W. Gereau,Mark J. Miller,Zhou-Feng Chen,Hongzhen Hu,Steve Davidson,Qin Liu,Brian S. Kim +26 more
TL;DR: An evolutionarily conserved paradigm is revealed in which the sensory nervous system employs classical immune signaling pathways to influence mammalian behavior, including chronic itch.
851
TSLP elicits IL-33–independent innate lymphoid cell responses to promote skin inflammation
Brian S. Kim,Mark C. Siracusa,Steven A. Saenz,Mario Noti,Laurel A. Monticelli,Gregory F. Sonnenberg,Matthew R. Hepworth,Abby S. Van Voorhees,Michael R. Comeau,David Artis +9 more
TL;DR: It is shown that ILC2s are always present in healthy skin, but accumulate in AD lesions and function by a mechanism that contrasts what has been reported in lungs and intestine, suggesting that targeting group 2 ILCs will be a viable target for treating AD and other allergic diseases.
725
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
Mark C. Siracusa,Steven A. Saenz,David A. Hill,Brian S. Kim,Mark B. Headley,Travis A. Doering,E. John Wherry,Heidi K. Jessup,Lori Siegel,Taku Kambayashi,Emily Dudek,Masato Kubo,Antonella Cianferoni,Jonathan M. Spergel,Steven F. Ziegler,Michael R. Comeau,David Artis +16 more
TL;DR: It is demonstrated that T SLP promotes systemic basophilia, that disruption of TSLP–TSLPR interactions results in defective basophil responses, and that TSLPR-sufficient basophils can restore TH2-cell-dependent immunity in vivo.
480
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
Ben Roediger,Ryan Kyle,Kwok Ho Yip,Nital Sumaria,Nital Sumaria,Thomas V. Guy,Brian S. Kim,Andrew J. Mitchell,Szun S. Tay,Rohit Jain,Elizabeth Forbes-Blom,Xi Chen,Philip L. Tong,Philip L. Tong,Philip L. Tong,Holly A. Bolton,David Artis,William E. Paul,Barbara Fazekas de St Groth,Barbara Fazekas de St Groth,Michele A. Grimbaldeston,Graham Le Gros,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger +24 more
TL;DR: The data show that ILC2 cells have both pro- and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.