Brian Riesenberg
Ohio State University
23 Papers
17 Citations
Brian Riesenberg is an academic researcher from Ohio State University. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Brian Riesenberg include Medical University of South Carolina.
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Papers
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.
Saleh Rachidi,Alessandra Metelli,Brian Riesenberg,Bill X. Wu,Michelle H. Nelson,Caroline Wallace,Chrystal M. Paulos,Mark P. Rubinstein,Elizabeth Garrett-Mayer,Mirko Hennig,Daniel W. Bearden,Yi Yang,Bei Liu,Zihai Li,Zihai Li +14 more
TL;DR: It is concluded that platelets constrain T cell immunity through a GARP-TGFβ axis and suggest a combination of immunotherapy and platelet inhibitors as a therapeutic strategy against cancer.
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β
Alessandra Metelli,Bill X. Wu,Brian Riesenberg,Silvia Guglietta,John D. Huck,Catherine M. Mills,Anqi Li,Saleh Rachidi,Carsten Krieg,Mark P. Rubinstein,Daniel T. Gewirth,Shaoli Sun,Michael B. Lilly,Amy H. Wahlquist,David P. Carbone,Yiping Yang,Bei Liu,Zihai Li,Zihai Li +18 more
TL;DR: A direct link between thrombin catalytic activity and release of mature TGF-β1 from platelets is shown and it is proposed that blockade of GARP cleavage is a valuable therapeutic strategy to overcome cancer’s resistance to immunotherapy.
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The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities.
TL;DR: The principal mechanisms by which ER stress affects immune cell biology and function are reviewed, with a focus of discussion on UPR-associated immunopathology and the development of potential ER stress-targeted therapeutics.
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
Ephraim A. Ansa-Addo,Jessica E. Thaxton,Feng Hong,Bill X. Wu,Yongliang Zhang,Caroline W. Fugle,Alessandra Metelli,Brian Riesenberg,Katelyn Williams,Daniel T. Gewirth,Gabriela Chiosis,Bei Liu,Zihai Li +12 more
TL;DR: The strategically important oncogenic clients of gp96 are discussed and the roles of cell-intrinsic gp96 in T cell biology are discussed, in part because it offers another opportunity of cancer therapy by manipulating levels of gp 96 in T cells to enhance host immune defense.
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling
Ephraim A. Ansa-Addo,Yongliang Zhang,Yi Yang,George S. Hussey,Breege V. Howley,Mohammad Salem,Brian Riesenberg,Shaoli Sun,Don C. Rockey,Serhan Karvar,Philip H. Howe,Bei Liu,Zihai Li +12 more
TL;DR: Moesin is established as an important regulator of the surface abundance and stability of T&bgr;RII and identifies moesin’s role in facilitating the efficient generation of iTregs, and suggests that modulation of moesIn is a potential therapeutic target for Treg-related immune disorders.