Brian Pedersen
University of California, San Diego
29 Papers
163 Citations
Brian Pedersen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Tissue factor & Inflammation. The author has an hindex of 19, co-authored 27 publications. Previous affiliations of Brian Pedersen include University of Michigan & Scripps Research Institute.
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Papers
Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia
Rafal Pawlinski,Brian Pedersen,Gernot Schabbauer,Michael Tencati,Todd Holscher,William A. Boisvert,Patricia Andrade-Gordon,Rolf Dario Frank,Nigel Mackman +8 more
TL;DR: Data demonstrate that hematopoietic cells are the major pathologic site of TF expression during endotoxemia and suggest that multiple protease-activated receptors mediate crosstalk between coagulation and inflammation.
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Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance
Sanjeev K. Upadhyay,Kristin Eckel-Mahan,M. Reza Mirbolooki,Indra W. Tjong,Stephen M Griffey,Galina Schmunk,Amanda Koehne,Briac Halbout,Shawn P. Iadonato,Brian Pedersen,Emiliana Borrelli,Ping H. Wang,Jogeshwar Mukherjee,Paolo Sassone-Corsi,K. George Chandy +14 more
TL;DR: ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 potassium channel, has powerful antiobesity effects in a mouse model of diet-induced obesity and counteracts the negative effects of increased caloric intake in mice fed a diet rich in fat and fructose.
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Pro- and anti-inflammatory eicosanoids in psoriatic arthritis
Roxana Coras,Roxana Coras,Arthur Kavanaugh,Tristan Boyd,Quyen Huynh,Brian Pedersen,Aaron M. Armando,Signe Dahlberg-Wright,Sara Marsal,Mohit Jain,Taraneh Paravar,Oswald Quehenberger,Monica Guma,Monica Guma +13 more
TL;DR: Both pro- and anti-inflammatory eicosanoids were associated with joint disease score, potentially representing pathways of harm as well as benefit in patients with PsA.
•Journal Article
A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice Against Leishmania major Infection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice
Claudia Raja Gabaglia,Brian Pedersen,Mary Hitt,Nicolas Burdin,Eli E. Sercarz,Frank L. Graham,Jack Gauldie,Todd A. Braciak +7 more
TL;DR: The results suggest the potential use of recombinant adenoviruses expressing cytokines as potent immunomodulatory agents for the generation of protective immune responses against intracellular pathogens.
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Atherosclerosis in Mice Is Not Affected by a Reduction in Tissue Factor Expression
Rachel E. Tilley,Brian Pedersen,Rafal Pawlinski,Yuichiro Sato,Yuichiro Sato,Jonathan Erlich,Yuechun Shen,Yuechun Shen,Sharlene M. Day,Ying Huang,Daniel T. Eitzman,William A. Boisvert,Linda K. Curtiss,William P. Fay,Nigel Mackman +14 more
TL;DR: The data indicate that either a 50% reduction of TF in all cells or a selective reduction in hematopoietic cell-derived TF does not affect the development of atherosclerotic lesions in mice.
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