Brian Luke
University of Mainz
76 Papers
273 Citations
Brian Luke is an academic researcher from University of Mainz. The author has contributed to research in topics: Biology & Telomere. The author has an hindex of 28, co-authored 60 publications. Previous affiliations of Brian Luke include University of Geneva & ETH Zurich.
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Papers
Regulatory R-loops as facilitators of gene expression and genome stability.
Christof Niehrs,Brian Luke +1 more
TL;DR: The cellular processes that regulatory R-loops modulate, the regulation of R-Loops and the potential differences that may exist may be discussed, including transcription termination and other steps of gene regulation, telomere stability and DNA repair.
404
The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae
TL;DR: It is demonstrated that telomeres are also transcribed in Saccharomyces cerevisiae by RNA polymerase II (RNAPII) and telomeric transcription combined with Rat1p-dependent TERRA degradation is important for regulating telomerase in yeast.
336
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
Bettina Balk,André Maicher,Martina Dees,Julia Klermund,Sarah Luke-Glaser,Katharina Bender,Brian Luke +6 more
TL;DR: It is shown that RNA-DNA hybrids form at telomeres and are removed by RNase H enzymes in the budding yeast, Saccharomyces cerevisiae, and regulation of TERRA transcription and telomeric RNA- DNA–hybrid formation are important determinants of both telomere-length dynamics and proliferative potential after the inactivation of telomerase.
290
TERRA: telomeric repeat-containing RNA.
Brian Luke,Joachim Lingner +1 more
TL;DR: TERRA functions that are emerging suggest important roles in the regulation of telomerase and in orchestrating chromatin remodelling throughout development and cellular differentiation.
Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.
Matthias Gstaiger,Brian Luke,Daniel Hess,Edward J. Oakeley,Christiane Wirbelauer,Marc Blondel,Marc Vigneron,Matthias Peter,Wilhelm Krek +8 more
TL;DR: Functional analysis of the yeast and human orthologs of URI revealed that both are targets of nutrient signaling and participate in gene expression controlled by the TOR kinase, suggesting that URI is a component of a signaling pathway that coordinates nutrient availability with gene expression.
190