Brian J. Sheahan
University College Dublin
64 Papers
785 Citations
Brian J. Sheahan is an academic researcher from University College Dublin. The author has contributed to research in topics: Semliki Forest virus & Virus. The author has an hindex of 27, co-authored 64 publications. Previous affiliations of Brian J. Sheahan include Trinity College, Dublin.
Chat about Author
Papers
Effect of alphavirus infection on mouse embryos.
TL;DR: It is concluded that A7 can traverse both the blood-brain barrier and the placenta, whereas M103 can traverse neither.
19
Teratogenicity of the Semliki Forest virus mutant ts22 for the foetal mouse: induction of skeletal and skin defects.
M. J. E. M. F. Mabruk,A. M. Flack,Gwendoline M. Glasgow,J. M. B. Smyth,J. C. Folan,J. G. Bannigan,O'Sullivan Ma,Brian J. Sheahan,Gregory J. Atkins +8 more
TL;DR: It is proposed that the skeletal and skin defects induced in mouse foetuses by ts22 infection result from the tropism of the virus for mesenchymal cells involved in the development of such tissue.
18
Multiple sclerosis and molecular mimicry.
TL;DR: A potential instance of molecular mimicry of human PLP, a major component of CNS 1985, is found and a previously unreported similarity between this same region of PLP and the stalk region of the measles fusion glycoprotein is found.
17
Effect of infection with the ts22 mutant of Semliki Forest virus on development of the central nervous system in the fetal mouse.
M. J. E. M. F. Mabruk,G M Glasglow,A. M. Flack,J. C. Folan,J. G. Bannigan,J. M. B. Smyth,O'Sullivan Ma,Brian J. Sheahan,Gregory J. Atkins +8 more
TL;DR: It was shown that the skin and musculoskeletal systems of fetuses from mothers infected with ts22 were often heavily infected but the central nervous systems were not labeled before day 17 of pregnancy, which appeared to be indirect and caused by virus infection of mesenchymal cells surrounding the developing neural tube.
Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection.
TL;DR: Treatment of mice with the pan MMP inhibitor GM6001 ameliorated the development of SFV-induced neuropathological lesions via an effect on the integrity of the blood-brain barrier.
16