Brian J. Allen
University of Minnesota
4 Papers
87 Citations
Brian J. Allen is an academic researcher from University of Minnesota. The author has contributed to research in topics: Spinal cord & Nociception. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Brian J. Allen include Veterans Health Administration.
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Papers
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Patrick W. Mantyh,Scott D. Rogers,Scott D. Rogers,Prisca Honore,Prisca Honore,Brian J. Allen,Brian J. Allen,Joseph R. Ghilardi,Joseph R. Ghilardi,Jun Li,Randy S. Daughters,Douglas A. Lappi,Ronald G. Wiley,Donald A. Simone +13 more
TL;DR: In this paper, a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, and it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor.
654
Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury.
Brian J. Allen,Jun Li,Patrick M. Menning,Scott D. Rogers,Joseph R. Ghilardi,Patrick W. Mantyh,Patrick W. Mantyh,Donald A. Simone +7 more
TL;DR: Results indicate that activation of small-caliber afferent fibers contributes to the enhanced SPR internalization in the spinal cord after nerve transection and inflammation and suggest that recruitment of neurons that possess the SPR contributes to hyperalgesia.
87
Transmission of chronic nociception by spinal neurons expressing the substance P receptor.
Michael L. Nichols,Michael L. Nichols,Brian J. Allen,Brian J. Allen,Scott D. Rogers,Scott D. Rogers,Joseph R. Ghilardi,Joseph R. Ghilardi,Prisca Honore,Prisca Honore,Nancy M. Luger,Nancy M. Luger,Matthew P. Finke,Matthew P. Finke,Jun Li,Douglas A. Lappi,Donald A. Simone,Patrick W. Mantyh,Patrick W. Mantyh +18 more
TL;DR: It is suggested that the small population of SPR-expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain.
Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: Imaging peptide action in vivo
Brian J. Allen,Scott D. Rogers,Joseph R. Ghilardi,Patrick M. Menning,Michael A. Kuskowski,Allan I. Basbaum,Donald A. Simone,Patrick W. Mantyh +7 more
TL;DR: The data suggest that thermal stimuli induce a graded release of SP from primary afferent terminals and that agonist dependent receptor endocytosis provides evidence of a spatially and pharmacologically unique “neurochemical signature” after specific somatosensory stimuli.