Brian Evans
GlaxoSmithKline
9 Papers
73 Citations
Brian Evans is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Oxytocin Antagonist & Ligand (biochemistry). The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Brian Evans include University of Hertfordshire.
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Papers
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Woodrow Michael David,Stuart P. Ballantine,Michael David Barker,Beth J. Clarke,John Dawson,Tony W. Dean,Christopher J. Delves,Brian Evans,Sharon Lisa Gough,Steven B. Guntrip,Stuart Holman,Duncan S. Holmes,Michael Kranz,Mika K. Lindvaal,Fiona S. Lucas,Margarete Neu,Lisa E. Ranshaw,Yemisi E. Solanke,Don O. Somers,Ward Peter,Joanne O. Wiseman +20 more
TL;DR: Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat.
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Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth.
Michael D. Wall,Michael Oshin,Gavin A.C. Chung,Tony Parkhouse,Andrea Gore,Esperanza Herreros,Brian Cox,Ken Duncan,Brian Evans,Martin J. Everett,Alfonso Mendoza +10 more
TL;DR: The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug.
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Identification of a Potent and Selective Oxytocin Antagonist, from Screening a Fully Encoded Differential Release Combinatorial Chemical Library.
TL;DR: A library of 1,296 1,4-benzodiazepines was prepared on 160 microM Tentagel beads using orthogonally cleavable linkers as mentioned in this paper.
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Patent
Acylated Piperidines as Glycine Transporter Inhibitors
Daniel Marcus Bradley,Clive Leslie GlaxoSmithKline Branch,Wai Ngor GlaxoSmithKline Chan,Steven GlaxoSmithKline Coulton,Dean Anthony William,Paul M. Doyle,Brian Evans,Martin Leonard Gilpin,Sharon Lisa Gough,Jacqueline Anne Macritchie,Howard Robert Marshall,David John GlaxoSmithKline Nash,Roderick Alan Porter,Simon E. Ward +13 more
- 09 Mar 2006
TL;DR: In this article, a compound of formula (I) or a salt or solvate thereof is defined, wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds.
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