Brian E. Root
University of Virginia
24 Papers
175 Citations
Brian E. Root is an academic researcher from University of Virginia. The author has contributed to research in topics: Chemistry & Matrix (chemical analysis). The author has an hindex of 12, co-authored 21 publications. Previous affiliations of Brian E. Root include Lockheed Martin Corporation & Northwestern University.
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Papers
Ultrafast DNA sequencing on a microchip by a hybrid separation mechanism that gives 600 bases in 6.5 minutes
Christopher P. Fredlake,Daniel G. Hert,Cheuk-Wai Kan,Thomas N. Chiesl,Brian E. Root,Ryan E. Forster,Annelise E. Barron +6 more
TL;DR: These results reveal the surprisingly powerful ability of microchip electrophoresis to provide ultrafast Sanger sequencing, which will translate to increased system throughput and reduced costs.
A centrifugal microfluidic device with integrated gold leaf electrodes for the electrophoretic separation of DNA
Brandon L. Thompson,Christopher Birch,Daniel Nelson,Jingyi Li,Jacquelyn A. DuVall,Delphine Le Roux,An-Chi Tsuei,Daniel L. Mills,Brian E. Root,James P. Landers +9 more
TL;DR: A unique, multi-level, centrifugal microdevice that can perform both reagent loading and DNA separation and is an ideal candidate for further integration and development of an inexpensive, portable and rapid forensic human identification system.
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Purification of HIV RNA from serum using a polymer capture matrix in a microfluidic device.
TL;DR: The gag region of HIV at a starting concentration of 37.5 copies per microliter was successfully purified from a 10% serum sample demonstrating the applicability of this method to detect viruses present in low copy numbers.
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Rapid Fabrication of Electrophoretic Microfluidic Devices from Polyester, Adhesives and Gold Leaf
Christopher Birch,Jacquelyn A. DuVall,Delphine Le Roux,Brandon L. Thompson,An-Chi Tsuei,Jingyi Li,Daniel Nelson,Daniel L. Mills,James P. Landers,Brian E. Root +9 more
TL;DR: In this article, a heat-sensitive adhesive (HSA) material was used to equip the microfluidic devices with the durability and resilience required for commercialization and fieldwork, without sacrificing any of the characteristics which make the PCL approach attractive for prototyping.
A rotationally-driven polyethylene terephthalate microdevice with integrated reagent mixing for multiplexed PCR amplification of DNA
Jacquelyn A. DuVall,Delphine Le Roux,An-Chi Tsuei,Brandon L. Thompson,Christopher Birch,Jingyi Li,Daniel Nelson,Daniel L. Mills,Margaret M. Ewing,Robert S. McLaren,Douglas R. Storts,Brian E. Root,James P. Landers +12 more
TL;DR: The resultant system represents a novel microfluidic PCR amplification platform that uses inexpensive PCR microdevices that are simple to fabricate, yet effective for complex, multiplexed PCR.
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