Brian E. McLaughlin
Queen's University
51 Papers
1.1K Citations
Brian E. McLaughlin is an academic researcher from Queen's University. The author has contributed to research in topics: Heme oxygenase & Nitric oxide. The author has an hindex of 23, co-authored 51 publications.
Chat about Author
Papers
Does carbon monoxide have a physiological function
TL;DR: Gerald Marks and colleagues suggest that carbon monoxide, which is formed endogenously from heme catabolism and which shares some of the chemical and biological properties of nitric oxide, may play a similar role.
448
•Journal Article
Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations.
Scott D. Appleton,Marc L Chretien,Brian E. McLaughlin,Hendrik J. Vreman,David K. Stevenson,James F. Brien,Kanji Nakatsu,Donald H. Maurice,Gerald S. Marks +8 more
TL;DR: CrMP, at a concentration of 5 microM, was a selective inhibitor of HO activity and was the most useful metalloporphyrin for the conditions tested, suggesting that CrMP would appear to be a valuable chemical probe in elucidating the physiological role of HO.
197
Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone
Flavio Coceani,Lois Kelsey,Eric Seidlitz,Gerald S. Marks,Brian E. McLaughlin,H J Vreman,David K. Stevenson,Marlene Rabinovitch,Cameron Ackerley +8 more
TL;DR: It is concluded that CO is formed in the ductus and may exert a relaxing influence when its synthesis is upregulated by an appropriate stimulus.
128
•Journal Article
Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta.
James F. Brien,Brian E. McLaughlin,T H Breedon,Brian M. Bennett,Kanji Nakatsu,Gerald S. Marks +5 more
TL;DR: Tissue GTN concentration was similar for both GTN-tolerant and nontolerant RAS, which indicated that the tissue uptake of GTN was similar and that GTN biotransformation was diminished in tolerant tissue.
126
Measurement of endogenous carbon monoxide formation in biological systems.
TL;DR: Endogenous carbon monoxide formation has been measured in different biological systems using a variety of analytical procedures and ranged from a low of 0.029 nmol/mg of protein/h in chorionic villi of term human placenta to a high of 0% in rat olfactory receptor neurons in culture and rat liver perfusate.
99