Brian E. Marron
Durham University
23 Papers
239 Citations
Brian E. Marron is an academic researcher from Durham University. The author has contributed to research in topics: Sodium channel blocker & Sodium channel. The author has an hindex of 14, co-authored 23 publications. Previous affiliations of Brian E. Marron include Pfizer.
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Papers
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Michael F. Jarvis,Prisca Honore,Char Chang Shieh,Mark L. Chapman,Shailen K. Joshi,Xu Feng Zhang,Michael E. Kort,William A. Carroll,Brian E. Marron,Robert N. Atkinson,James Thomas,Dong Liu,Michael J. Krambis,Yi Liu,Steve McGaraughty,Katharine L. Chu,Rosemarie Roeloffs,Chengmin Zhong,Joseph P. Mikusa,Gricelda Hernandez,Donna M. Gauvin,Carrie Wade,Chang Zhu,Madhavi Pai,Marc J. C. Scanio,Lei Shi,Irene Drizin,Robert J. Gregg,Mark A. Matulenko,Ahmed A. Hakeem,Michael L. Gross,Matthew D. Johnson,Kennan C. Marsh,P. Kay Wagoner,James P. Sullivan,Connie R. Faltynek,Douglas S. Krafte +36 more
TL;DR: A-803467 is found, a sodium channel blocker that potently blocks tetrodotoxin-resistant currents and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons and produces significant antinociception in animal models of neuropathic and inflammatory pain.
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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels
Ken McCormack,Sonia Santos,Mark L. Chapman,Douglas S. Krafte,Brian E. Marron,Christopher William West,Michael J. Krambis,Brett M Antonio,Shannon G. Zellmer,David Printzenhoff,Karen Padilla,Zhixin Lin,P. Kay Wagoner,Nigel Alan Swain,Stupple Paul Anthony,Marcel J. de Groot,Richard P. Butt,Neil A. Castle +17 more
TL;DR: A new class of subtype selective small molecule sodium channel inhibitors that interact with a region of the channel that controls voltage sensitivity is described, which may enable development of selective therapeutic interventions with reduced potential for toxicity.
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
Aristos J. Alexandrou,Adam R. Brown,Mark L. Chapman,Mark Estacion,Jamie Turner,Malgorzata A. Mis,Anna Wilbrey,Elizabeth C. Payne,Alex Gutteridge,Peter J. Cox,Rachel Doyle,David Printzenhoff,Zhixin Lin,Brian E. Marron,Christopher William West,Nigel Alan Swain,R. Ian Storer,Stupple Paul Anthony,Neil A. Castle,James A. Hounshell,Mirko Rivara,Andrew D. Randall,Sulayman D. Dib-Hajj,Douglas S. Krafte,Stephen G. Waxman,Manoj K. Patel,Richard P. Butt,Edward B. Stevens +27 more
TL;DR: It is reported that Nav1.7 is the predominant functional TTX-sensitive Nav in mouse and human nociceptors and contributes to the initiation and the upstroke phase of the nOCiceptor action potential, and a role for Nav 1.7 in influencing synaptic transmission in the dorsal horn of the spinal cord as well as peripheral neuropeptide release in the skin is confirmed.
Recent progress in sodium channel modulators for pain.
Sharan K. Bagal,Mark L. Chapman,Brian E. Marron,Rebecca L. Prime,R. Ian Storer,Nigel Alan Swain +5 more
TL;DR: Emerging clinical data combined with recent breakthroughs in Nav structural biology pave the way for a future of fruitful prospective Nav drug discovery.
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Voltage gated sodium channels as drug discovery targets
TL;DR: The structure, function and the state of the art in sodium channel modulator drug discovery are discussed in this chapter.
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