Brian E. Howard
Research Triangle Park
30 Papers
185 Citations
Brian E. Howard is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Alternative splicing & Computer science. The author has an hindex of 12, co-authored 30 publications. Previous affiliations of Brian E. Howard include Johns Hopkins University & North Carolina State University.
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Papers
SWIFT-Review: a text-mining workbench for systematic review
Brian E. Howard,Jason Phillips,Kyle Miller,Arpit Tandon,Deepak Mav,Mihir Shah,Stephanie Holmgren,Katherine E. Pelch,Vickie R. Walker,Andrew A. Rooney,Malcolm R. Macleod,Ruchir R. Shah,Kristina A. Thayer +12 more
TL;DR: Overall, these results suggest that using machine learning to triage documents for screening has the potential to save, on average, more than 50 % of the screening effort ordinarily required when using un-ordered document lists.
SWIFT-Active Screener: Accelerated document screening through active learning and integrated recall estimation.
Brian E. Howard,Jason Phillips,Arpit Tandon,Adyasha Maharana,Rebecca Elmore,Deepak Mav,Alex Sedykh,Kristina A. Thayer,B. Alex Merrick,Vickie R. Walker,Andrew A. Rooney,Ruchir R. Shah +11 more
TL;DR: SWIFT-Active Screener, a web-based, collaborative systematic review software application, designed to reduce the overall screening burden required during this resource-intensive phase of the review process, and the integration of explicit recall estimation during screening solves an important challenge faced by all machine learning systems for document screening.
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Additional file 6: of SWIFT-Review: a text-mining workbench for systematic review
Brian E. Howard,Jason Phillips,Kyle Miller,Arpit Tandon,Deepak Mav,Mihir Shah,Stephanie Holmgren,Katherine E. Pelch,Vickie R. Walker,Andrew A. Rooney,Malcolm R. Macleod,Ruchir R. Shah,Kristina A. Thayer +12 more
- 01 Jan 2016
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Accessible proteomics space and its implications for peak capacity for zero-, one- and two-dimensional separations coupled with FT-ICR and TOF mass spectrometry
TL;DR: The results indicate that reverse-phase-nanoHPLC (RP-nHPLC) separation coupled with FT-ICR MS offers an order of magnitude improvement in peak capacity over RP- nHPLC separation coupling with TOF MS, and the addition of an orthogonal separation method, strong cation exchange (SCX), for 2D LC-MS demonstrates an additional 10-fold improvement inpeak capacity over 1D LC -MS methods.
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Effect of Vaccination with a Recombinant Fusion Protein Encoding an Astacinlike Metalloprotease (MTP-1) Secreted by Host-Stimulated Ancylostoma caninum Third-Stage Infective Larvae
Peter J. Hotez,James Ashcom,Bin Zhan,Jeffrey M. Bethony,Alex Loukas,John M. Hawdon,Yang Wang,Qun Jin,Karen Jones,Azra Dobardzic,Reshad Dobardzic,Janelle Bolden,Idong Essiet,Walter E. Brandt,Philip K. Russell,Bernard C. Zook,Brian E. Howard,Marco Chacon +17 more
TL;DR: Spearman rank order correlations between the canine intestinal adult hookworm burden and quantitative egg counts at necropsy and anti-Ac-MTP-1 IgG2 antibody titers revealed a statistically significant inverse association, suggesting that this molecule offers promise as a recombinant vaccine.
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