Brian D Burt
Princess Margaret Cancer Centre
6 Papers
Brian D Burt is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Human leukocyte antigen & Epitope. The author has an hindex of 2, co-authored 3 publications.
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Papers
Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma.
Kenji Murata,Munehide Nakatsugawa,Muhammed A. Rahman,Linh T. Nguyen,Douglas G. Millar,David T. Mulder,Kenji Sugata,Hiroshi Saijo,Yukiko Matsunaga,Yuki Kagoya,Tingxi Guo,Mark Anczurowski,Chung-Hsi Wang,Chung-Hsi Wang,Brian D Burt,Dalam Ly,Kayoko Saso,Alexandra M. Easson,David P. Goldstein,Michael Reedijk,Michael Reedijk,Michael Reedijk,Danny A Ghazarian,Trevor J. Pugh,Marcus O. Butler,Tak W. Mak,Tak W. Mak,Pamela S. Ohashi,Pamela S. Ohashi,Naoto Hirano +29 more
TL;DR: This work systematically and comprehensively mapped shared antigenic epitopes recognized by tumor-infiltrating T lymphocytes from eight melanoma patients for all their class I alleles, allowing for a more complete examination of the immune response and development of novel cancer immunotherapy not limited by HLA allele prevalence or tumor mutation burden.
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Changing the landscape of tumor immunology: novel tools to examine T cell specificity.
TL;DR: Outstanding recent contributions to T cell research will help close the gap between knowledge and proof of function and application and potentially bring practical benefit to patients.
2
Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation
Kenji Murata,Dalam Ly,Hiroshi Saijo,Yukiko Matsunaga,Kenji Sugata,Fumie Ihara,Daisuke Oryoji,Yota Ohashi,Kayoko Saso,Chung-Hsi Wang,Evey Y F Zheng,Brian D Burt,Mark S. Butler,Naoto Hirano +13 more
TL;DR: This study provides an example of how modifications to the HLA binding pocket can enhance wild-type cognate peptide presentation to heighten T cell activation, and identifies an alanine 81 to leucine (A81L) modification within the F binding pocket of HLA-A*24:02 that was found toheighten the ability of artificial APCs to retain and present HLA–A* 24:02–restricted peptides.
1
The adaptor protein VEPH1 interacts with the kinase domain of ERBB2 and impacts EGF signaling in ovarian cancer cells.
TL;DR: In this article , the adaptor protein ventricular zone-expressed pleckstrin homology domain-containing protein 1 (VEPH1) was identified as a potential interacting partner of ERBB2 in a screen of proteins co-immunoprecipitated with VEPH1.
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.
Kenji Sugata,Yukiko Matsunaga,Yuki Yamashita,Munehide Nakatsugawa,Tingxi Guo,Levon Halabelian,Yota Ohashi,Yota Ohashi,Kayoko Saso,Muhammed A. Rahman,Mark Anczurowski,Mark Anczurowski,Chung-Hsi Wang,Chung-Hsi Wang,Kenji Murata,Hiroshi Saijo,Yuki Kagoya,Dalam Ly,Brian D Burt,Marcus O. Butler,Marcus O. Butler,Tak W. Mak,Tak W. Mak,Naoto Hirano,Naoto Hirano +24 more
TL;DR: In this paper, the authors used a combination of molecular biological and immunological techniques to clone sequences encoding human leukocyte antigen (HLA)-DP, HLA-DQ and HLADR molecules with enhanced CD4 binding affinity.