A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)

Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum

Lycium barbarum (Gouqizi, Fructus Lycii, Wolfberry) is well known for nourishing the liver, and in turn, improving the eyesight. However, many people have forgotten its anti-aging properties. Valuable components of L. barbarum are not limited to its colored components containing zeaxanthin and carotene, but include the polysaccharides and small molecules such as betaine, cerebroside, β-sitosterol, p-coumaric, and various vitamins. Despite the fact that L. barbarum has been used for centuries, its beneficial effects to our bodies have not been comprehensively studied with modern technology to unravel its therapeutic effects at the biochemical level. Recently, our laboratory has demonstrated its neuroprotective effects to counter neuronal loss in neurodegenerative diseases. Polysaccharides extracted from L. barbarum can protect neurons against β-amyloid peptide toxicity in neuronal cell cultures, and retinal ganglion cells in an experimental model of glaucoma. We have even isolated the active component of polysaccharide which can attenuate stress kinases and pro-apoptotic signaling pathways. We have accumulated scientific evidence for its anti-aging effects that should be highlighted for modern preventive medicine. This review is to provide background information and a new direction of study for the anti-aging properties of L. barbarum. We hope that new findings for L. barbarum will pave a new avenue for the use of Chinese medicine in modern evidence-based medicine.

Use of Anti-aging Herbal Medicine, Lycium barbarum , Against Aging-associated Diseases. What Do We Know So Far?

Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.

Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults.

A topical composition according to the present invention for use in a skin care regimen that provides matrix metalloprotease (MMP) inhibiting activity, tissue inhibitor of metalloprotease (TIMP) inducing activity, and immediate and delayed antioxidative activity. Preferably, the topical composition comprises at least one MMP inhibitor, a TIMP inducing agent, Tremella fuciformis (snow fungus) extract, Camellia sinensis (green tea) leaf extract, and Eugenia caryophyllus (clove) extract. The compositions are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and preventing skin damage.

Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities

A cosmetic skin care composition includes salicylhydroxamate or one or more other hydroxamate derivatives in an amount of about 0.001% to about 10.0% by weight, and nordihydroguaiaretic acid or one or more other antioxidants in an amount of about 0.00001% to about 10% by weight. The composition can be optionally encapsulated in a liposomal vehicle.

Cosmetic compositions containing combinations of hydroxamate derivatives and antioxidants in a liposomal delivery system

An extract of the marine algae, Sarcodiotheca, and more particularly Sarcodiotheca gaudichaudii, is described for use in cosmetic compositions. A biofermentation of Sarcodiotheca, such as for example S. gaudichaudii, is also described. This marine bioferment is useful as a skin care active ingredient for anti-aging cosmetic applications, and particularly useful when used in combination with an extracts of red algae, such as Chondrus crispus.

Marine extracts and biofermentations for use in cosmetics

A skin care active complex in accordance with an embodiment of the invention comprises a combination of (1) from about 0.001% to about 10% by weight, preferably from about 0.001% to about 5% by weight, of a vitamin A derivative; (2) from about 0.00001% to about 10% by weight of a hydroxamate derivative; (3) from about 0.01% to about 5% by weight of an anti-inflammatory natural compound; and optionally, (1) from about 0.001% to about 10% by weight of vitamin K.

Skin care active complex and methods of using same

A skin care composition which comprises one or more K vitamins in an amount of from about 0.001% to about 10% by weight, one or more vitamin A derivatives in an amount of about 0.001% to about about 5% by weight, one or more hydroxamate derivatives in an amount of about 0.00001% to about 10% by weight, and one or more natural anti-inflammatory compounds in an amount of about 0.01% by weight. about 5% by weight, products containing it and processes using it.

Skin care composition useful to prevent wrinkles and to treat acne comprises vitamin K, vitamin A derivatives, hydroxamate derivatives and natural anti-inflammatory compounds drugs

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