Brian Charest
Harvard University
21 Papers
14 Citations
Brian Charest is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 4 publications. Previous affiliations of Brian Charest include Veterans Health Administration.
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Papers
Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
Danielle Rasooly,Gina M. Peloso,Alexandre C. Pereira,Hesamaddin Torabi Dashti,Claudia Giambartolomei,Eleanor Wheeler,Nay Aung,B. Ferolito,Maik Pietzner,Eric Farber-Eger,Quinn S. Wells,Nicole M Kosik,Liam Gaziano,Daniel Posner,A. Patrícia Bento,Qin Hui,Chang Liu,Krishna G. Aragam,Zeyuan Wang,Brian Charest,Jennifer E. Huffman,Peter W.F. Wilson,L. Phillips,John C. Whittaker,Patricia B. Munroe,Steffen E. Petersen,Kelly Cho,Andrew R. Leach,María Paula Magariños,J. Michael Gaziano,Claudia Langenberg,Yan V. Sun,Jacob Joseph,Juan P. Casas +33 more
TL;DR: A large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry is conducted to uncover novel genetic determinants for heart failure.
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Mendelian randomization study of diabetes and dementia in the Million Veteran Program.
Elizabeth Litkowski,Mark W. Logue,Rui Zhang,Brian Charest,Ethan M. Lange,John E. Hokanson,Julie Lynch,Marijana Vujkovic,Lawrence S. Phillips,Richard L. Hauger,Leslie A. Lange,Sridharan Raghavan +11 more
TL;DR: In this article , a one-sample Mendelian randomization (MR) analysis in the US Department of Veterans Affairs Million Veteran program was conducted to evaluate evidence of causality between these two common diseases.
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Trends in 30-day mortality from COVID-19 among older adults in the Veterans Affairs system.
TL;DR: The brunt of mortality related to coronavirus disease 2019 (COVID-19) has been borne by older adults as mentioned in this paper, with over 80% of all deaths occurring among people over the age of 65 years.
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30‐day mortality following COVID‐19 and influenza hospitalization among US veterans aged 65 and older
Benjamin Seligman,Brian Charest,Yuk-Lam Ho,Hanna Gerlovin,Rachel E. Ward,Kelly Cho,Jane A. Driver,J. Michael Gaziano,David R. Gagnon,Ariela R. Orkaby +9 more
TL;DR: This work compared outcomes from infection with COVID‐19 and influenza among hospitalized older adults and found no significant difference in outcomes for older adults with either infection.
6
Genome-wide association analysis and Mendelian randomization proteomics identify novel protein biomarkers and drug targets for primary prevention of heart failure
Danielle Rasooly,Gina M. Peloso,Alexandre C. Pereira,Hamed Dashti,Claudia Giambartolomei,Eleanor Wheeler,Nweni Aung,B. Ferolito,Mike Pietzner,Nicole M Kosik,Liam Gaziano,Daniel Posner,A. Patrícia Bento,Qin Hui,C. Liu,Krishna G. Aragam,Z. Wang,Brian Charest,Jennifer E. Huffman,Peter W.F. Wilson,L. Phillips,John C. Whittaker,Patricia B. Munroe,S. Petersen,Kelly Cho,Andrew R. Leach,María Paula Magariños,John Michael Gaziano,VA Million Veteran Program,Claudia Langenberg,Yi Sun,Jacob Joseph,Juan P. Casas +32 more
TL;DR: A large-scale meta-analysis of heart failure genome-wide association studies (GWAS) and MR-proteomics identified seven proteins as potential targets for interventions to be used in primary prevention of HF and identified 10 additional putatively causal genes for HF.