Brian C. Murphy
Johns Hopkins University School of Medicine
5 Papers
112 Citations
Brian C. Murphy is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Extracellular matrix & Extracellular. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Brian C. Murphy include Johns Hopkins University.
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Papers
Modifications of the intermediate filament and nuclear matrix networks by the extracellular matrix.
TL;DR: Interaction of normal rat kidney epithelial cells (NRK) and Kirsten-ras transformed rat kidney cells, with an extracellular matrix secreted by tumor cells, causes modifications to the protein composition of the intermediate filament and nuclear matrix networks.
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The effect of extracellular matrix interactions on morphologic transformation invitro
TL;DR: The effect of extracellular matrices secreted from both normal and tumor cells have on the structure of normal rat kidney epithelial cells is reported.
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Effect of pentosan, a novel cancer chemotherapeutic agent, on prostate cancer cell growth and motility.
TL;DR: In vivo,pentosan prolongs survival of rats injected with MLL cells by 25%, but did not appear to decrease the rate of primary tumor growth or the number of metastatic lesions in the treated animals, suggesting that, in vivo, pentosan acts through an as yet undefined mechanism.
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Effects of extracellular matrix components and dihydrotestosterone on the structure and function of human prostate cancer cells.
TL;DR: It is determined that the ECM and DHT interact in complex ways to effect cell structure and function and these data exemplify the complex interactions which occur between prostate cancer cells, ECM components, and exogenous DHT that are reflected in cellructure and function.
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The Tissue Matrix and The Regulation of Gene Expression in Cancer Cells
TL;DR: Tensegrity was defined in 1948 by Buckminster Fuller as a structural system composed of discontinuous compression elements connected by continuous tension cables, and several investigators have now demonstrated this type of tension derived system operating in living cells.
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