Brian A. Cooke
Royal Free Hospital
91 Papers
1.5K Citations
Brian A. Cooke is an academic researcher from Royal Free Hospital. The author has contributed to research in topics: Leydig cell & Luteinizing hormone. The author has an hindex of 31, co-authored 91 publications. Previous affiliations of Brian A. Cooke include University of London & University Hospital of Wales.
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Papers
Stimulation and inhibition by LHRH analogues of cultured rat Leydig cell function and lack of effect on mouse Leydig cells
TL;DR: Results show that LHRH analogues do not bind to or have any detectable effect on mouse Leydig cells in vitro, however, L HRH analogue does bind specifically to purified rat LeydIG cells.
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Signal transduction involving cyclic AMP-dependent and cyclic AMP-independent mechanisms in the control of steroidogenesis.
TL;DR: It is concluded that while cAMP is a second messenger for LH/ACTH in the control of steroidogenesis, other signalling systems exist which are potentially equally effective in controlling steroidogenesis.
130
The effect of cell damage on the density and steroidogenic capacity of rat testis Leydig cells, using an NADH exclusion test for determination of viability.
Louise F. Aldred,Brian A. Cooke +1 more
TL;DR: It is concluded that the methods used to prepare and purify rat testis Leydig cells contribute to the apparent Leydigs cell "heterogeneity".
116
Direct inhibition of ovarian steroidogenesis by Cortisol and the modulatory role of 11β‐hydroxysteroid dehydrogenase
TL;DR: The objectives of this study were to investigate the direct effects of Cortisol on luteinizing hormone (LH) action in human granulosa‐lutein cells and the modulation of this interaction by ovarian 11β‐Miydroxysteroid dehydrogenase (11βHSD).
111
Purification and characterization of Leydig cells from rat testes.
TL;DR: An LH-responsive Leydig cell preparation was obtained by collagenase treatment of rat testis and the highest testosterone response was obtained with 100-1000 ng LH/ml when the pre-incubation period was omitted.
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