Brenda W.J.H. Penninx
VU University Amsterdam
1217 Papers
9.5K Citations
Brenda W.J.H. Penninx is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Anxiety & Medicine. The author has an hindex of 170, co-authored 1139 publications. Previous affiliations of Brenda W.J.H. Penninx include University of Amsterdam & University of Jyväskylä.
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Papers
Huntingtin gene repeat size variations affect risk of lifetime depression
Sarah L. Gardiner,Martine J. van Belzen,Merel W. Boogaard,Willeke M. C. van Roon-Mom,Maarten Pieter Rozing,Albert M. van Hemert,Johannes H. Smit,Aartjan T.F. Beekman,Gerard van Grootheest,Robert A. Schoevers,Richard C. Oude Voshaar,Raymund A.C. Roos,Hannie C. Comijs,Brenda W.J.H. Penninx,Roos C. van der Mast,Roos C. van der Mast,N. Ahmad Aziz +16 more
TL;DR: Lifetime depression risk was higher with both relatively short and relatively large HTT CAG repeat sizes in the normal range, providing important proof-of-principle that repeat polymorphisms can act as hitherto unappreciated but complex genetic modifiers of depression.
Psychological distress, cortisol stress response and subclinical coronary calcification
TL;DR: Long-term but not current psychological distress is associated with severe CAC in healthy older subjects and participants with both long-term distress and increased cortisol response were especially at risk for severe calcification.
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Childhood trauma and dysregulation of multiple biological stress systems in adulthood: Results from the Netherlands Study of Depression and Anxiety (NESDA)
Erika Kuzminskaite,Christiaan H. Vinkers,Bernet M. Elzinga,Klaas J. Wardenaar,Erik J. Giltay,Brenda W.J.H. Penninx +5 more
TL;DR: While the findings do not provide conclusive evidence on CT directly dysregulating stress systems, individuals with severe CT showed slight indications of dysregulations, partially explained by an unhealthy lifestyle and poorer health.
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The Associations Between Personality Characteristics and Absenteeism: A Cross-Sectional Study in Workers With and Without Depressive and Anxiety Disorders
M.C. Vlasveld,M.C. Vlasveld,Christina M. van der Feltz-Cornelis,Christina M. van der Feltz-Cornelis,Johannes R. Anema,Johannes R. Anema,Willem van Mechelen,Willem van Mechelen,Aartjan T.F. Beekman,Harm W.J. van Marwijk,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx +12 more
TL;DR: In this paper, the authors examined the associations of the Big 5 personality characteristics (neuroticism, extraversion, openness, agreeableness and conscientiousness) and locus of control with absenteeism, taking the presence of depressive and anxiety disorders into account.
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Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts
Giorgio Pistis,Yuri Milaneschi,Caroline L. Vandeleur,Aurélie M. Lasserre,Brenda W.J.H. Penninx,Femke Lamers,Dorret I. Boomsma,Jouke-Jan Hottenga,Pedro Marques-Vidal,Peter Vollenweider,Gérard Waeber,Jean-Michel Aubry,Martin Preisig,Zoltán Kutalik,Zoltán Kutalik +14 more
TL;DR: In this article, the authors investigated the potential causal role of obesity in both the atypical subtype and its five specific symptoms assessed according to the Statistical Manual of Mental Disorders (DSM), in two large European cohorts, CoLaus|PsyCoLaus (n = 3350, 1461 cases and 1889 controls) and NESDA|NTR (n= 4139, 1182 cases and 2957 controls).