Brandon Holtrup
Yale University
9 Papers
Brandon Holtrup is an academic researcher from Yale University. The author has contributed to research in topics: Adipose tissue & White adipose tissue. The author has an hindex of 9, co-authored 9 publications.
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Papers
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
TL;DR: It is shown that high-fat diet feeding in mice rapidly and transiently induces proliferation of APs within WAT to produce new adipocytes, which indicates that developmental and obesogenic adipogenesis are regulated through distinct molecular mechanisms.
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Guillermo C. Rivera-Gonzalez,Brett A. Shook,Johanna Andrae,Brandon Holtrup,Katherine Bollag,Christer Betsholtz,Matthew S. Rodeheffer,Valerie Horsley +7 more
TL;DR: The molecular and genetic studies uncover PI3K/AKT2 as a direct PDGFA target that is activated in ASCs during WAT hyperplasia and is functionally required for dermal ASC proliferation, and show that distinct regulatory mechanisms operate in different WAT depots.
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Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
Rachel K. Zwick,Michael C. Rudolph,Brett Ba Shook,Brandon Holtrup,Eve Roth,Vivian Lei,Alexandra Van Keymeulen,Victoria L. Seewaldt,Stephanie L. Kwei,John J. Wysolmerski,Matthew Ms Rodeheffer,Valerie Horsley +11 more
TL;DR: It is demonstrated that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression during involution and an essential role for adipocytes in milk trafficking from, and proper restructuring of, the mammary epithelium is revealed.
MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors
Thalyana Smith-Vikos,Alexandre de Lencastre,Sachi Inukai,Mariel Shlomchik,Brandon Holtrup,Frank J. Slack +5 more
TL;DR: By interacting with PHA-4 and SKN-1, miRNAs transduce the effect of dietary-restriction-mediated lifespan extension in C. elegans and are discovered new links in an important pathway connecting DR to aging.
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Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis.
Brandon Holtrup,Christopher D. Church,Ryan Berry,Laura Colman,Elise Jeffery,Jeremy Bober,Matthew S. Rodeheffer +6 more
- 03 Jul 2017
TL;DR: The period of development associated with puberty, postnatal days 18–34, is identified as critical for the establishment of normal adipose mass in mice, indicating that exposure to obesogenic stimuli during critical developmental periods have prolonged effects on adipose tissue function that may contribute to the exacerbated metabolic dysfunctions associated with childhood obesity.
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