Brandon E. Armstead
The Feinstein Institute for Medical Research
5 Papers
Brandon E. Armstead is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Autoimmune Disease–Associated Haplotypes of BLK Exhibit Lowered Thresholds for B Cell Activation and Expansion of Ig Class‐Switched B Cells
Kim R. Simpfendorfer,Brandon E. Armstead,Andrew Shih,Wentian Li,Mark Curran,Nataly Manjarrez-Orduño,Annette Lee,Betty Diamond,Peter K. Gregersen +8 more
TL;DR: This study characterized the BLK risk haplotype and determined associated B cell functional phenotypes involved in autoimmunity to characterize the mechanisms by which reduced expression alters human B cell function to confer autoimmune disease susceptibility.
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Biogenesis of JC polyomavirus associated extracellular vesicles
Jenna Morris-Love,Bethany A. O'Hara,Gretchen V. Gee,Aisling S. Dugan,Ryan O'Rourke,Brandon E. Armstead,Benedetta Assetta,Sheila A. Haley,Walter J. Atwood +8 more
TL;DR: In this paper , a combination of chemical and genetic approaches were used to show that several overlapping intracellular pathways are responsible for the biogenesis of virus containing extracellular vesicle (EV) mediated infection.
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Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression
Michelle Wakeley,Brandon E. Armstead,Chyna C. Gray,Elizabeth Tindal,Daithi S. Heffernan,Chun-Shiang Chung,Alfred Ayala +6 more
TL;DR: In this article , varying severity of severe injury induces immunosuppression and variable increases in HVEM/BTLA leukocyte co-expression in the thymic and splenic immune compartments.
Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung
Brandon E. Armstead,Yaping P. Chen,Runping Zhao,Chun-Shiang Chung,Alger M. Fredericks,Sean F. Monaghan,Alfred Ayala +6 more
TL;DR: In this paper , a single cell multi-omics approach was used to identify novel phenotype specific pathways potentially contributing to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in mice.
P-1990. RNA Sequencing Identifies Antimicrobial Resistance Genes Directly from Peripheral Blood of Patients
G. J. Nau,Jaewook Shin,Brandon E. Armstead,Alfred Ayala,M. Cohen,W. Fairbrother,Alger M. Fredericks,Mitchell M. Levy,E. Raggi,Kwesi K. Lillard,Gregory Jay,Sean F Monaghan +11 more
TL;DR: This study uses RNA sequencing to identify antimicrobial resistance (AMR) genes directly from peripheral blood of patients with sepsis, revealing efflux pumps as a significant AMR mechanism, and demonstrating RNA sequencing's potential for dynamic AMR assessment.