Bram Slütter
Leiden University
82 Papers
144 Citations
Bram Slütter is an academic researcher from Leiden University. The author has contributed to research in topics: Chemistry & Immune system. The author has an hindex of 29, co-authored 58 publications. Previous affiliations of Bram Slütter include University of Iowa & Roy J. and Lucille A. Carver College of Medicine.
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Papers
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Marie A.C. Depuydt,Koen H.M. Prange,Lotte Slenders,Tiit Örd,Danny Elbersen,Arjan Boltjes,Saskia C.A. de Jager,Folkert W. Asselbergs,Gert J. de Borst,Einari Aavik,Tapio Lönnberg,Esther Lutgens,Christopher K. Glass,Hester M. den Ruijter,Minna U. Kaikkonen,Ilze Bot,Bram Slütter,Sander W. van der Laan,Seppo Ylä-Herttuala,Michal Mokry,Johan Kuiper,Menno P.J. de Winther,Gerard Pasterkamp +22 more
TL;DR: This detailed definition of cell communities at play in atherosclerosis will facilitate cell-based mapping of novel interventional targets with direct functional relevance for the treatment of human disease.
408
Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity
Bram Slütter,Bram Slütter,Natalija Van Braeckel-Budimir,Georges Abboud,Steven M. Varga,Shahram Salek-Ardakani,John T. Harty +6 more
TL;DR: Time-dependent changes in expression of genes critical for lymphocyte trafficking and TRM differentiation, in concert with enrichment of TCM, diminish the capacity of circulating memory CD8 T cells to form TRM with time, explaining why IAV-induced TRM are not stably maintained.
Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems
Deepa Mohanan,Bram Slütter,Malou Henriksen-Lacey,Wim Jiskoot,Joke A. Bouwstra,Yvonne Perrie,Thomas M. Kündig,Bruno Gander,Pål Johansen +8 more
TL;DR: The results show that the IgG2aassociated with Th1-type immune responses are sensitive to the route of administration, whereas IgG1 response associated with Th2- type immune responses were relatively insensitive to the administration route of the particulate delivery systems.
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PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity.
TL;DR: The pros and cons of using PLGA particulate formulations for subunit vaccine delivery are discussed and an overview of formulation parameters that influence their adjuvanticity and the ensuing immune response is provided.
Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen.
Bram Slütter,Suzanne M. Bal,Chantal Keijzer,Roel Mallants,Niels Hagenaars,Ivo Que,Eric L. Kaijzel,Willem van Eden,Patrick Augustijns,Clemens W.G.M. Löwik,Joke A. Bouwstra,Femke Broere,Wim Jiskoot +12 more
TL;DR: For nasal vaccination, TMC NP, releasing their content within several hours, being mucoadhesive and stimulating the maturation of DC, were superior to PLGA NP and PLGA/TMC NP which lacked some or all of these characteristics.
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